Anti-Aging · Reference
SYNAPSE Blend Dosage: How Pepti Prescribes Semax, Selank, MOTS-c and Tesamorelin in One Vial
This page explains the SYNAPSE dosage Pepti prescribes, what the units on the syringe mean, how much of each of the four peptides is in one dose, a units to mL to mg chart for the SYNAPSE vial, how a SYNAPSE dose compares with Semax, Selank, MOTS-c and tesamorelin on their own and with the ELEVATE blend, when it is taken, and what can change your directions. It covers how Pepti prescribes SYNAPSE, not online protocols. Nothing here is a reason to change your own dose.
Treatments mentioned
At Pepti, the SYNAPSE blend is prescribed as 0.25 mL, which is 25 units on a U-100 insulin syringe, injected under the skin once daily Monday through Friday. The 5 mL vial holds 5 mg Semax, 5 mg Selank, 10 mg MOTS-c and 10 mg tesamorelin, so every 0.25 mL dose delivers 0.25 mg Semax, 0.25 mg Selank, 0.5 mg MOTS-c and 0.5 mg tesamorelin, and the vial holds 20 doses, about four weeks. Your physician sets your directions after reviewing your intake, and your exact dose and units are printed on the vial.
This page explains the SYNAPSE dosage Pepti prescribes, what the units on the syringe mean, how much of each of the four peptides is in one dose, a units to mL to mg chart for the SYNAPSE vial, how a SYNAPSE dose compares with Semax, Selank, MOTS-c and tesamorelin on their own and with the ELEVATE blend, when it is taken, and what can change your directions. It covers how Pepti prescribes SYNAPSE, not online protocols. Nothing here is a reason to change your own dose.
SYNAPSE Blend Dosage
The short answer
| Product | Vial | Directions | Per dose | Doses per vial | Price |
|---|---|---|---|---|---|
| SYNAPSE Blend | 5 mL: Semax 1 mg/mL, Selank 1 mg/mL, MOTS-c 2 mg/mL, tesamorelin 2 mg/mL | Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday | 0.25 mg Semax, 0.25 mg Selank, 0.5 mg MOTS-c, 0.5 mg tesamorelin | 20 | $279/mo |
The price is all-in, covering medication, physician review, refill management and shipping, with no separate membership fee. Pepti is cash-pay and does not bill insurance. Your own directions are the ones printed on your vial.
SYNAPSE Blend Dosage
SYNAPSE dosage in units, mL and mg
Pepti's directions are written in millilitres and units, because prescriptions are written in millilitres and insulin syringes are marked in units. On a U-100 insulin syringe, 1 unit is 0.01 mL, so 100 units is 1 mL and 25 units is 0.25 mL. A unit is a volume mark on the barrel, not a measure of how strong the medication is.
SYNAPSE is four peptides dissolved together in one vial, so one draw carries all four. The milligrams per dose come from each component's concentration multiplied by 0.25 mL:
| Component | Concentration | Per vial | Per 0.25 mL dose |
|---|---|---|---|
| Semax | 1 mg/mL | 5 mg | 0.25 mg |
| Selank | 1 mg/mL | 5 mg | 0.25 mg |
| MOTS-c | 2 mg/mL | 10 mg | 0.5 mg |
| Tesamorelin | 2 mg/mL | 10 mg | 0.5 mg |
| Total | 30 mg | 1.5 mg |
That arithmetic is a way to read a label, not a way to set a dose. A vial labelled with 30 mg of peptide in total is not a 30 mg dose: it is twenty doses of 1.5 mg combined. If your label and your syringe seem to disagree, do not dose; message your care team. How long does a peptide vial last explains every number on a vial label.
Fixed proportions
The four peptides are in a ratio fixed by the pharmacy's formulation. Every dose delivers the same split, and there is no way to take more of one and less of another from the same vial. MOTS-c and tesamorelin are 20 of the 30 mg, two-thirds of the vial by mass, so although SYNAPSE sits in Pepti's cognitive category, by weight it is mostly a metabolic preparation with two smaller neuropeptide components. If a different balance is wanted, the components are prescribed separately.
SYNAPSE Blend Dosage
SYNAPSE dosage chart: units to mL to mg
The chart below is the conversion for the SYNAPSE vial, drawn with a U-100 insulin syringe. It is math only. It is not a menu of doses, and the only line that applies to you is the one that matches the number printed on your vial.
| Syringe mark (U-100) | Volume | Semax | Selank | MOTS-c | Tesamorelin |
|---|---|---|---|---|---|
| 5 units | 0.05 mL | 0.05 mg | 0.05 mg | 0.1 mg | 0.1 mg |
| 10 units | 0.1 mL | 0.1 mg | 0.1 mg | 0.2 mg | 0.2 mg |
| 15 units | 0.15 mL | 0.15 mg | 0.15 mg | 0.3 mg | 0.3 mg |
| 20 units | 0.2 mL | 0.2 mg | 0.2 mg | 0.4 mg | 0.4 mg |
| 25 units (Pepti's typical directions) | 0.25 mL | 0.25 mg | 0.25 mg | 0.5 mg | 0.5 mg |
| 50 units | 0.5 mL | 0.5 mg | 0.5 mg | 1 mg | 1 mg |
| 100 units | 1 mL | 1 mg | 1 mg | 2 mg | 2 mg |
The rule behind every row: units divided by 100 gives millilitres; multiply millilitres by 1 for Semax and Selank and by 2 for MOTS-c and tesamorelin. Those multipliers only hold for this vial. A chart written for a different blend or a different concentration gives different milligram figures for the same units, which is the main reason not to dose from a chart, including this one.
SYNAPSE Blend Dosage
SYNAPSE compared with the products next to it
People often compare a SYNAPSE dose with the single-peptide vials, or with the ELEVATE blend, which shares the same Semax and Selank. The draw is 25 units in each, but what that draw delivers differs:
| SYNAPSE | Semax | Selank | MOTS-c | Tesamorelin | ELEVATE | |
|---|---|---|---|---|---|---|
| What is in the vial | 5 mL: 5 mg Semax, 5 mg Selank, 10 mg MOTS-c, 10 mg tesamorelin | 5 mL: 10 mg Semax | 5 mL: 10 mg Selank | 5 mL: 10 mg MOTS-c | 5 mL: 10 mg tesamorelin | 5 mL: 5 mg Semax, 5 mg Selank, 10 mg BPC-157, 10 mg KPV |
| Typical directions | 0.25 mL once daily, Monday through Friday | 0.25 mL once daily, Monday through Friday | 0.25 mL once daily, Monday through Friday | 0.25 mL Monday through Friday mornings | 0.25 mL Monday through Friday nights at bedtime | 0.25 mL once daily, Monday through Friday |
| Per dose | 0.25 mg Semax, 0.25 mg Selank, 0.5 mg MOTS-c, 0.5 mg tesamorelin | 0.5 mg Semax | 0.5 mg Selank | 0.5 mg MOTS-c | 0.5 mg tesamorelin | 0.25 mg Semax, 0.25 mg Selank, 0.5 mg BPC-157, 0.5 mg KPV |
| Doses per vial | 20 | 20 | 20 | 20 | 20 | 20 |
| Price | $279/mo | $229/mo | $229/mo | $259/mo | $249/mo | $249/mo |
What the numbers show
Three things stand out. First, a SYNAPSE dose carries the same 0.5 mg of MOTS-c as the MOTS-c vial and the same 0.5 mg of tesamorelin as the tesamorelin vial, so the metabolic side of the blend is not diluted. Second, it carries half the Semax and half the Selank of the single-peptide vials, because those vials are 2 mg/mL and SYNAPSE carries each at 1 mg/mL. Third, SYNAPSE and ELEVATE deliver identical Semax and Selank per dose; they differ only in their partners, MOTS-c and tesamorelin in SYNAPSE, BPC-157 and KPV in ELEVATE.
Why there is no reason to stack SYNAPSE with its components
Adding a tesamorelin, MOTS-c, Semax or Selank vial on top of SYNAPSE would put more of that component into each day than either product's directions describe. The same applies to other blends that share components: FUSION and PHYSIQ both contain tesamorelin and MOTS-c. Whether any combination suits you is set by your physician after reviewing your intake, which asks for every product you take for this reason.
Compared with the trial doses
The tesamorelin in each SYNAPSE dose is 0.5 mg on weekdays. The approved tesamorelin product's trials used 2 mg daily for visceral fat, and the 2012 cognition trial in older adults used 1 mg nightly for 20 weeks. The Semax and Selank human studies used intranasal products, so there is no injected trial dose to compare with. MOTS-c has no human trials at all. A SYNAPSE dose is not a scaled-down version of any studied dose.
SYNAPSE Blend Dosage
When SYNAPSE is taken
Once daily, Monday through Friday
Pepti's SYNAPSE directions say once daily, Monday through Friday, with weekends off. Weekends off are part of the schedule, not missed doses. Twenty doses at five a week is four working weeks, which is why refills run on a 28-day cycle. The weekday-only pattern is a prescribing convention rather than a schedule taken from any trial.
Time of day
The printed SYNAPSE directions say once daily without naming a time, and the components pull in different directions. The single tesamorelin vial is directed at bedtime, because tesamorelin is described as amplifying the growth hormone pulse of early sleep and the 2012 cognition trial dosed at bedtime. The single MOTS-c vial is directed in the morning, and Semax is linked to restlessness if taken late in the day. The live SYNAPSE reference notes that some prescribers direct it in the evening and others in the morning. If your label names a time, follow the label.
Under the skin, and where
Subcutaneous means into the fat layer, not the muscle. Abdomen and thigh are the usual sites, rotated so the same spot is not used repeatedly. The route is systemic, so there is no "near the problem" site. Technique is covered in how to inject peptides safely.
Directions say What it means in practice 0.25 mL (25 units) Draw to the 25 mark on a U-100 insulin syringe Subcutaneously Into the fat layer, abdomen or thigh, rotating sites Once daily One injection per dosing day Monday through Friday Five doses a week, weekends off 20 doses per vial About four weeks, then the next refill
SYNAPSE Blend Dosage
How long a SYNAPSE vial lasts, storage and refills
| Step | Value |
|---|---|
| Dose | 25 units, 0.25 mL |
| Doses per week | 5 (Monday through Friday) |
| Doses per vial | 20 (5 mL divided by 0.25 mL) |
| Used over the vial | 5 mg Semax, 5 mg Selank, 10 mg MOTS-c, 10 mg tesamorelin, the whole vial |
| Time per vial | 20 doses divided by 5 per week = 4 weeks |
Vials are multi-dose solutions shipped ready to use, refrigerated with ice packs, with sterile syringes and alcohol prep pads. Nothing is mixed at home. Keep it in the fridge, do not freeze or shake it, and follow the beyond-use date on the label, which runs from first puncture; a multi-peptide vial is not something to keep past it. Cloudiness, particles or a change from what you received is a reason to message rather than inject. One vial per fill, every 28 days. How to store peptides covers storage.
If a vial runs short before the refill, message your care team rather than adjusting anything yourself. If you miss a weekday dose, follow your directions and do not take two doses to make up for one.
SYNAPSE Blend Dosage
Why the research cannot give you a SYNAPSE dose
SYNAPSE has never been studied as a blend, in people or in animals, so there is no trial dose for it. The evidence is per component, and none of it is a dose study of this injection. Tesamorelin has randomized trials of the approved product at 1 to 2 mg daily. Semax's Russian clinical series and Selank's small Russian comparator trials used intranasal products. MOTS-c has mouse and cell work only. The directions on the vial are a prescribing standard set to deliver one vial in four weeks. The component evidence is laid out in SYNAPSE blend benefits and what is the SYNAPSE blend.
SYNAPSE Blend Dosage
What changes the directions
Your physician sets your directions after reviewing your intake. Things that can lead to different directions, or a different product, include:
| What can change | How it shows up |
|---|---|
| Whether SYNAPSE is the right formula | Focus and stress alone may point to Semax, Selank or Semax + Selank; body composition alone to tesamorelin or FUSION; a gut complaint with focus to ELEVATE |
| Time of day | Some directions name a morning or evening time |
| Diabetes or borderline glucose | Tesamorelin can raise blood sugar; MOTS-c is described in mice improving insulin sensitivity |
| Existing psychiatric treatment or a stimulant | Reviewed at intake; none has been studied alongside Semax or Selank |
| A cancer history or a pituitary problem | The approved tesamorelin product is contraindicated in active malignancy and in disruption of the pituitary axis |
| How you respond | Reactions you report go to your physician, who may revise your directions |
When directions change, the new numbers are printed on the new label. Never carry a number over from a previous fill. Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account.
SYNAPSE Blend Dosage
Side effects, in summary
| What is reported | What it tracks | What to do |
|---|---|---|
| Injection-site redness, mild soreness, occasional bruising | Any injection; tesamorelin's label records it most | Rotate sites |
| Joint aches, swelling in the hands or feet, tingling | Tesamorelin (fluid-related growth hormone effects) | Message your care team |
| Thirst or frequent urination | A possible rise in blood sugar (tesamorelin) | Message your care team |
| Brief jitteriness, a faster pulse or light-headedness after a dose | MOTS-c | Usually settles; report it if not |
| Restlessness if dosed late in the day | Semax | Tell your care team; do not change timing yourself |
| Early nausea or light-headedness | Reported for the blend | Report it if it persists |
| Facial or throat swelling, widespread rash, breathing difficulty | Possible with any injected medication | Call 911 first, then tell your physician |
The full list, with who should not take SYNAPSE, is in SYNAPSE blend side effects. Tested athletes should know that the 2026 WADA Prohibited List names tesamorelin under S2.2.4 and MOTS-c under S4.4.1, both prohibited at all times, which covers SYNAPSE.
SYNAPSE is a compounded prescription; compounded medications are not FDA approved. In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted to recommend adding Semax and MOTS-c to the 503A Bulks List, with the FDA's final determinations pending. Selank's nomination was withdrawn and it has never been reviewed. Tesamorelin is the active ingredient of an FDA-approved product, but compounded tesamorelin is not that product.
SYNAPSE Blend Dosage
Where to get SYNAPSE prescribed
SYNAPSE cannot be bought legitimately without a prescription. Sites selling multi-peptide vials "for research use only" are not accountable for what is in them: identity, purity, sterility and concentration are untested, so the per-dose figures above would not hold. The prescription route:
- Complete a free online intake covering your history, medications and what you want help with.
- A physician licensed in your state reviews it, usually within 24 hours.
- If it is appropriate, a PCAB-accredited, FDA-registered US 503A compounding pharmacy prepares it to that prescription. Lot test results are published at /quality/lab-results.
- It ships refrigerated with your directions printed on the vial.
- Your physician stays reachable for questions and dose changes.
The components on their own: Semax dosage, Selank dosage, MOTS-c dosage and tesamorelin dosage.
References
What this is based on.
References
- Dolotov OV, Karpenko EA, Inozemtseva LS et al.. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus · Brain Res (2006) · PMID 16996037
- Lee C, Zeng J, Drew BG et al.. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance · Cell Metab (2015) · PMID 25738459
- Falutz J, Allas S, Blot K et al.. Metabolic effects of a growth hormone-releasing factor in patients with HIV · N Engl J Med (2007) · PMID 18057338
- Friedman SD, Baker LD, Borson S et al.. Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging · JAMA Neurol (2013) · PMID 23689947
- Baker LD, Barsness SM, Borson S et al.. Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial · Arch Neurol (2012) · PMID 22869065
- Stanley TL, Feldpausch MN, Oh J et al.. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial · JAMA (2014) · PMID 25038357
- Falutz J, Mamputu JC, Potvin D et al.. Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data · J Clin Endocrinol Metab (2010) · PMID 20554713
- Falutz J, Potvin D, Mamputu JC et al.. Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension · J Acquir Immune Defic Syndr (2010) · PMID 20101189
- Stanley TL, Fourman LT, Feldpausch MN et al.. Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial · Lancet HIV (2019) · PMID 31611038
- Makimura H, Feldpausch MN, Rope AM et al.. Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial · J Clin Endocrinol Metab (2012) · PMID 23015655
- Dal J, Leisner MZ, Hermansen K et al.. Cancer Incidence in Patients With Acromegaly: A Cohort Study and Meta-Analysis of the Literature · J Clin Endocrinol Metab (2018) · PMID 29590449
- Johannsson G, Touraine P, Feldt-Rasmussen U et al.. Long-term Safety of Growth Hormone in Adults With Growth Hormone Deficiency: Overview of 15 809 GH-Treated Patients · J Clin Endocrinol Metab (2022) · PMID 35368070
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Common questions
SYNAPSE Blend Dosage, answered.
At Pepti, 0.25 mL, which is 25 units on a U-100 insulin syringe, injected subcutaneously once daily Monday through Friday. Your physician sets your directions after reviewing your intake, and your exact dose is printed on the vial.
At 0.25 mL: 0.25 mg Semax, 0.25 mg Selank, 0.5 mg MOTS-c and 0.5 mg tesamorelin, 1.5 mg combined. The split is fixed by the formulation.
The number printed on your vial. Pepti's typical directions are 25 units, which is 0.25 mL on a U-100 insulin syringe, where 1 unit is 0.01 mL.
Twenty. A 5 mL vial divided by 0.25 mL per dose is 20 doses, four working weeks on a Monday to Friday schedule.
The chart above converts units to millilitres to milligrams of each component for the SYNAPSE vial. It is a conversion, not a list of doses to choose from. Your own label is the one that applies.
The printed directions say once daily without naming a time. Tesamorelin on its own is directed at bedtime, while MOTS-c is directed in the morning and Semax can cause restlessness late in the day, so prescribers vary. If your label names a time, follow it; if sleep is affected, message your care team.
For tesamorelin, yes: 25 units of SYNAPSE carries 0.5 mg, the same as 25 units from the tesamorelin vial. The same is true of MOTS-c. Semax and Selank are at half the single-vial amount.
Raise it with your physician first. Every SYNAPSE dose already carries all four components, and FUSION and PHYSIQ also contain tesamorelin and MOTS-c, so another product can double a component. The intake asks about everything you take for this reason.
Take the dose printed on your vial, on the schedule printed on your vial. If you have questions about your dose, message your care team.
No. Pepti vials are multi-dose solutions shipped ready to use, with sterile syringes and alcohol prep pads.
No. SYNAPSE is supplied as a vial with sterile syringes only, with no pen or capsule.
Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account. The free assessment goes to a physician licensed in your state. A consultation does not guarantee a prescription.
Next step
See what a physician recommends for you.
A licensed physician in your state reviews your intake and decides what is appropriate. A consultation does not guarantee a prescription.