MOTS-c (Injectable)
Mitochondrial optimization
The pepti Pen cartridge for this treatment is sold out right now. The vial is the same medication at our best price.
Choose your strength
Every strength is a 4-week supply. A higher strength means more medication per dose on the same monthly cycle. Your provider confirms the dose at review.
All-in monthly price · 10mg
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
MOTS-c (Injectable)
A mitochondrial-derived peptide that regulates metabolic homeostasis and cellular energy.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
Checks the active peptide against impurities and degradation products.
Confirms the peptide in the vial is the correct molecule.
Confirms the solution sits within the range specified for injection.
Checks the finished vial for visible and sub-visible particles.
Confirms the vial seal holds so sterility is maintained through the beyond-use date.
- Lot 100526-MOT-10
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.8%
- Lot 100526-MOT-12
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.4%
- Lot 100526-MOT-2
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.0%
How MOTS-c is prescribed.
- Adults focused on metabolic health, endurance, and insulin sensitivity
- Patients who want a mitochondrial-targeting peptide alongside training
Your physician decides whether MOTS-c is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously Monday through Friday mornings.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of MOTS-c.
Everything published
about MOTS-c.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How MOTS-c works, and what the research shows.
MOTS-c is a peptide encoded within mitochondrial DNA.
It regulates metabolic homeostasis, improves insulin sensitivity, and acts as an exercise mimetic — boosting cellular energy and metabolic flexibility.
MOTS-c was identified as a mitochondrial-derived peptide regulating metabolic homeostasis, where it improved insulin sensitivity and exercise capacity in mice.
Lee et al., Cell Metab 2015Levels rise with exercise in humans, and an analog has entered early-phase human trials for metabolic disease.
Direct human outcome data for MOTS-c itself remains limited — it is prescribed as an investigational metabolic peptide.
References
- Lee C, Zeng J, Drew BG et al.. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance · Cell Metab (2015) · PMID 25738459
- Reynolds JC, Lai RW, Woodhead JST et al.. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis · Nat Commun (2021) · PMID 33473109
- Kim KH, Son JM, Benayoun BA et al.. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress · Cell Metab (2018) · PMID 29983246
- Zempo H, Kim SJ, Fuku N et al.. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c · Aging (Albany NY) (2021) · PMID 33468709
- Ramanjaneya M, Bettahi I, Jerobin J et al.. Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects · Front Endocrinol (Lausanne) (2019) · PMID 31214116
- Cataldo LR, Fernández-Verdejo R, Santos JL et al.. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals · J Investig Med (2018) · PMID 29593067
- Lu H, Wei M, Zhai Y et al.. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction · J Mol Med (Berl) (2019) · PMID 30725119
- Ming W, Lu G, Xin S et al.. Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation · Biochem Biophys Res Commun (2016) · PMID 27237975
- Knoop A, Thomas A, Thevis M. Development of a mass spectrometry based detection method for the mitochondrion-derived peptide MOTS-c in plasma samples for doping control purposes · Rapid Commun Mass Spectrom (2019) · PMID 30394592
- Ozkaya DY, Haymana C, Demirci I et al.. MOTS-C levels in individuals with and without obesity and its association with inflammation, insulin resistance and endothelial dysfunction · Arch Endocrinol Metab (2025) · PMID 41004666
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
5 mL multi-dose vial, MOTS-C 2 mg/mL (10 mg MOTS-C per vial); as the Pen: 3 mL pre-filled Pen cartridge containing 30 mg MOTS-C
Frequently asked
about MOTS-c (Injectable).
A mitochondrial-derived peptide that regulates metabolic homeostasis and cellular energy. MOTS-c is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
MOTS-c is $259 per month at Pepti as a vial, or $339 as a pre-filled pepti Pen. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
MOTS-c is commonly prescribed for: Adults focused on metabolic health, endurance, and insulin sensitivity; Patients who want a mitochondrial-targeting peptide alongside training. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. MOTS-c is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. MOTS-c can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
MOTS-c is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account. It is also available as a pre-filled pepti Pen for $339.
33 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $259 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded MOTS-c with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of MOTS-c are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and MOTS-c is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add MOTS-c to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded MOTS-c is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only MOTS-c sold without a prescription is labeled not for human use and is a different product.
MOTS-c is a peptide encoded within mitochondrial DNA. At Pepti it is prescribed to support mitochondrial health, metabolic regulation, exercise mimetic, longevity. Individual response varies, and your physician sets expectations at approval.
MOTS-c is a peptide encoded within mitochondrial DNA. It regulates metabolic homeostasis, improves insulin sensitivity, and acts as an exercise mimetic — boosting cellular energy and metabolic flexibility. Compounded MOTS-c is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
MOTS-c is prescribed for mitochondrial health, metabolic regulation, exercise mimetic, longevity. It is commonly requested by adults focused on metabolic health, endurance, and insulin sensitivity; patients who want a mitochondrial-targeting peptide alongside training. Whether it is appropriate for you is the reviewing physician's decision.
MOTS-c is studied for mitochondrial health, metabolic regulation, exercise mimetic, longevity. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
MOTS-c was identified as a mitochondrial-derived peptide regulating metabolic homeostasis, where it improved insulin sensitivity and exercise capacity in mice (Lee et al., Cell Metab 2015). Levels rise with exercise in humans, and an analog has entered early-phase human trials for metabolic disease. Direct human outcome data for MOTS-c itself remains limited — it is prescribed as an investigational metabolic peptide. References are listed on this page.
MOTS-c is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules MOTS-c out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate MOTS-c is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $259 per month, all-in. Not prescribed means refunded.
Injectable vial: 10 mL at 2 mg/mL, containing 20 mg MOTS-c. Injectable vial: 5 mL at 6 mg/mL, containing 30 mg MOTS-c. Injectable vial: 5 mL at 10 mg/mL, containing 50 mg MOTS-c. Injectable vial: 5 mL at 2 mg/mL, containing 10 mg MOTS-c. Pepti Pen cartridge: 3 mL cartridge (300 units) at 10 mg/mL, containing 30 mg MOTS-c. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Yes. MOTS-c is available as a pre-filled pepti Pen cartridge for $339 per month, versus $259 as a vial. Same medication, same pharmacy; the reusable injector is free with your first pen order. Choose the format in the cart or ask your physician.
$259 per month covers the compounded MOTS-c, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. MOTS-c is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
MOTS-c ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$259 per month at Pepti as a vial, or $339 as a pepti Pen. That includes the compounded MOTS-c, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Yes. Pepti offers MOTS-c as a pre-filled pepti Pen cartridge for $339 per month, or as a vial for $259. The reusable injector is included free with your first pen order and tips come with every cartridge. Same medication, same pharmacy, physician-prescribed after a free online assessment.
Yes. Pepti prescribes MOTS-c online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $259 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then MOTS-c ships from the pharmacy. No clinic visit and no video appointment in most cases. $259 per month, all-in.
Yes, for the real thing. MOTS-c sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's MOTS-c is physician-prescribed, pharmacy-compounded, batch-tested, and $259 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $259 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed MOTS-c online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded MOTS-c is not FDA-approved.
$259 per month at Pepti, or $339 as a pepti Pen, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and MOTS-c ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose MOTS-c, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, MOTS-c ships within 1-3 business days and arrives in 1-3 more; if not, the $259 is refunded.
No. MOTS-c can be prescribed from the assessment alone at Pepti. Bloodwork is required only for GLP-1s and growth-hormone secretagogues.
Pepti ships MOTS-c to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about MOTS-c (Injectable).
- MOTS-c: What It Is, Where to Get It Prescribed, and What It CostsMOTS-c — 5 mL multi-dose vial, MOTS-C 2 mg/mL (10 mg MOTS-C per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Peptides for Longevity and Anti-Aging: What Is Actually Prescribed and What the Evidence SaysThe peptides used in longevity protocols, what each one does at the cellular level, which claims outrun the evidence, and what it costs.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- Do You Need a Doctor to Get Peptides? Yes, and Here Is Exactly WhyPeptides used clinically are prescription medications. Why a prescriber is legally required, what your own doctor will likely say, and what a real review looks like online.
- How to Inject Peptides Safely: Step by Step, Units, Sites and MistakesA practical subcutaneous injection walkthrough: reading your sig, converting millilitres to insulin-syringe units, the ten steps, site rotation, what to do about bubbles and missed doses.
Read more about MOTS-c (Injectable).
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