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Tirzepatide (Injectable)
Weight Loss

Tirzepatide (Injectable)

Next-gen weight loss

Your starting dose

New to this medication? Your provider starts you low and steps you up over time.

All-in monthly price

$159

No membership fee · this is the full price · free shipping · avg 4-week supply

Medication, provider care, labs & dose adjustments — all in one price.
~28-day supply. Your provider sets your exact dose, so yours may vary — your refill arrives as you finish the last one.
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Add in-depth bloodwork

Optional — add a physician-reviewed at-home blood panel to your plan.

At-home kit (1 device)+$149

Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.

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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Dr. Gene
Physician Reviewed

Reviewed by Dr. Gene, MD · Board-certified Family Medicine

Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.

About

Tirzepatide (Injectable)

Dual GIP and GLP-1 receptor agonist offering enhanced weight management benefits.

Benefits
Dual GIP/GLP-1 action
Superior weight loss
Metabolic health
Appetite reduction
Supply per fill
28-day

About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.

Physician review
24 hrs

A licensed US physician reviews your intake and prescribes when appropriate.

FDA-registered pharmacy
503A

Compounded fresh at a US pharmacy and shipped cold-chain to your door.

Shipping, always
Free

Every order ships free — medication, physician care and refills, one all-in price.

Formulation
Injectable vial2 mL
Tirzepatidecompounded to your dose
Glycineincluded

Strength is compounded to the exact dose your physician prescribes and stepped up over time.

Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.

Quality

Every batch independently tested

Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.

USP <71>
Sterility

Confirms the finished preparation is free of viable microorganisms.

USP <85>
Bacterial endotoxins

Screens for endotoxins that can cause fever or inflammatory reactions.

Assay
Potency

Verifies the labeled concentration of the active peptide is what is in the vial.

HPLC
Purity

Checks the active peptide against impurities and degradation products.

Mass spectrometry
Identity

Confirms the peptide in the vial is the correct molecule.

USP <791>
pH

Confirms the solution sits within the range specified for injection.

USP <788>
Particulate matter

Checks the finished vial for visible and sub-visible particles.

USP <1207>
Container closure integrity

Confirms the vial seal holds so sterility is maintained through the beyond-use date.

Recent lots
  • Lot 100526-TIR-10

    Tested 2026-10-07 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.2%

  • Lot 100526-TIR-20

    Tested 2026-10-07 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    100.2%

  • Lot 100526-TIR-30

    Tested 2026-10-07 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.4%

Compounded by licensed U.S. pharmacies. Prescribed by licensed medical providers. Shipped directly to patients.Documentation available upon request →View lab results by lot →
Your protocol

How Tirzepatide is prescribed.

Who it's for
  • Adults with a BMI in the range their physician considers appropriate for dual GIP/GLP-1 therapy
  • Patients who did not reach their goal on semaglutide
  • People who want physician-managed dose escalation rather than a fixed dose
  • Patients already on tirzepatide who want to continue at their current dose

Your physician decides whether Tirzepatide is appropriate for you after reviewing your intake and labs.

Directions & duration

Inject 0.50 mL (50 units) subcutaneously once weekly.

Cycle. Weekly injection. New to it? Dose steps up on a schedule set by your physician; you can request the next step when you're ready. Already on it? Choose your current dose when you order and your physician confirms it at review. Pricing is by dose.
Ready for more? When you're ready, ask your physician to step up to the next dose. Approved steps are charged at the price difference and applied to your next fill.
Directions shown are the pharmacy's standard for this preparation. Your prescription label is the final word.
What's included
  • Licensed physician review of your intake, history, and labs
  • Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
  • Every batch independently tested before release
  • Sterile syringes and alcohol prep pads for injectables
  • Tracked delivery to your door, refills on schedule
  • Message your physician anytime; dose changes without an appointment
Storage & handling
  • Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
  • One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
  • Protect from light. Wipe the stopper with an alcohol pad before every draw.
  • Dispose of syringes in the sharps container per the included instructions.
What to expect

A typical course of Tirzepatide.

TimeframeWhat patients commonly report
Weeks 1–4Reduced appetite and earlier fullness are the most common first changes. Mild nausea is common while the body adjusts; for patients new to the medication the starting dose is deliberately low. Already on it? Your provider can continue you at the dose you're on.
Weeks 5–12As the dose steps up under physician direction, weight change typically becomes measurable. Slower is safer.
Month 3 onwardOngoing physician monitoring; long-term results in studies depended on continued treatment alongside diet and activity.
Individual results vary. Compounded medications are not FDA-approved; a licensed physician determines whether treatment is appropriate and monitors your progress.
The full reference

Everything published
about Tirzepatide.

How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.

Read the reference
32
References

peer-reviewed, each verified on PubMed

15
Sections

mechanism, evidence, dosing, safety, FAQ

Oct 27
FDA status verified

2026 · checked against fda.gov, not memory

The science

How Tirzepatide works, and what the research shows.

How it works

Tirzepatide is a dual GIP/GLP-1 receptor agonist — it activates both incretin pathways instead of just one.

This dual action produces superior weight loss results vs semaglutide alone.

Phase 3 trials showed up to 22.5% body weight loss.

Clinical evidence
  • The SURMOUNT-1 trial randomized 2,539 adults with obesity to tirzepatide 5/10/15 mg vs placebo.

    Jastreboff et al., NEJM 2022
  • At 72 weeks, mean weight reductions were 15.0%, 19.5%, and 20.9% on the active arms vs 3.1% on placebo — the highest weight-loss outcomes recorded for a pharmacological intervention at the time.

  • SURMOUNT-2 confirmed efficacy in patients with type 2 diabetes, and the SURPASS program demonstrated superior HbA1c reduction vs semaglutide head-to-head.

    Frias et al., 2021
  • Tirzepatide's dual GIP+GLP-1 mechanism appears to drive both stronger appetite suppression and improved metabolic flexibility.

Full references with PubMed links are listed further down the page.

Tirzepatide (Injectable) vs. Mounjaro / Zepbound

Mounjaro / Zepbound
$1429
per month at brand-name pricing
pepti Tirzepatide (Injectable)
$159
~72% less than brand-name

Compounded at an FDA-registered 503A pharmacy. Compounded medications are not FDA-approved.

References

  1. Jastreboff AM, Aronne LJ, Ahmad NN, et al.. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) · New England Journal of Medicine (2022) · PMID 35658024
  2. Garvey WT, Frias JP, Jastreboff AM, et al.. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2) · Lancet (2023) · PMID 37385275
  3. Frías JP, Davies MJ, Rosenstock J, et al.. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2) · New England Journal of Medicine (2021) · PMID 34170647
  4. Inagaki N, Takeuchi M, Oura T, et al.. Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial · The Lancet Diabetes & Endocrinology (2022) · PMID 35468322
  5. Malhotra A, Grunstein RR, Fietze I, et al.. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) · New England Journal of Medicine (2024) · PMID 38912654
  6. Nicholls SJ, Pavo I, Bhatt DL, et al.. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes (SURPASS-CVOT) · New England Journal of Medicine (2025) · PMID 41406444
  7. Aronne LJ, Sattar N, Horn DB, et al.. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial · JAMA (2024) · PMID 38078870
  8. Pasternak B, Wintzell V, Hviid A et al.. Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study · BMJ (2024) · PMID 38683947
  9. Quddos F, Hubshman Z, Tegge A, et al.. Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity · Scientific Reports (2023) · PMID 38017205
  10. Drummond RF, Seif KE, Reece EA. Glucagon-like peptide-1 receptor agonist use in pregnancy: a review · Am J Obstet Gynecol (2025) · PMID 39181497
  11. Wang S, Sun J, Wang J, et al.. Does obesity based on body mass index affect semen quality? A meta-analysis and systematic review from the general population rather than the infertile population · Andrologia (2021) · PMID 34028074
  12. Urva S, Coskun T, Loghin C, et al.. The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists · Diabetes, Obesity and Metabolism (2020) · PMID 32519795
  13. Borner T, Geisler CE, Fortin SM, et al.. GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models · Diabetes (2021) · PMID 34380697
  14. Hróbjartsson A, Gøtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment · N Engl J Med (2001) · PMID 11372012
  15. Barnett AG, van der Pols JC, Dobson AJ. Regression to the mean: what it is and how to deal with it · Int J Epidemiol (2005) · PMID 15333621
  16. McCambridge J, Witton J, Elbourne DR. Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects · J Clin Epidemiol (2014) · PMID 24275499
  17. Heise T, DeVries JH, Urva S, et al.. Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes · Diabetes Care (2023) · PMID 36857477
  18. Schneck K, Urva S. Population pharmacokinetics of the GIP/GLP receptor agonist tirzepatide · CPT Pharmacometrics Syst Pharmacol (2024) · PMID 38356317
  19. Bochanen N, Decochez K, Heleu E, Cuypers J, et al.. Lipohypertrophy Monitoring Study (LIMO): Effect of single use of 4 mm pen needles combined with education on injection site rotation on glycaemic control: Confirmation of an unpleasant truth · Diabet Med (2022) · PMID 34407260
  20. Murao S, Murao K, Nagata T, Shimizu M. Repeated insulin injection without site rotation affects skin thickness - ultrasonographic and histological evaluation · J Diabetes Investig (2022) · PMID 35060349
  21. Deng N, Zhang X, Zhao F, Wang Y. Prevalence of lipohypertrophy in insulin-treated diabetes patients: A systematic review and meta-analysis · J Diabetes Investig (2017) · PMID 28862814
  22. Wadden TA, Chao AM, Machineni S, et al.. Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial · Nature Medicine (2023) · PMID 37840095
  23. Rosenstock J, Wysham C, Frías JP, et al.. Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial · Lancet (2021) · PMID 34186022
  24. Ludvik B, Giorgino F, Jódar E, et al.. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial · Lancet (2021) · PMID 34370970
  25. Del Prato S, Kahn SE, Pavo I, et al.. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial · Lancet (2021) · PMID 34672967
  26. Dahl D, Onishi Y, Norwood P, et al.. Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial · JAMA (2022) · PMID 35133415
  27. Guo L, Klonoff DC, Al Sifri SN, Bee YM et al.. Consensus Recommendations on Lipohypertrophy: Insights From an International Panel of Experts · Diabetes Research and Clinical Practice (2026) · PMID 42398590
  28. Sattar N, Linetzky B, Ruotolo G et al.. Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide: A SURMOUNT-1 Post Hoc Analysis · J Am Coll Cardiol (2026) · PMID 42233927
  29. Coskun T, Sloop KW, Loghin C, et al.. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept · Molecular Metabolism (2018) · PMID 30473097
  30. Sattar N, McGuire DK, Pavo I, et al.. Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis · Nature Medicine (2022) · PMID 35210595
  31. Samms RJ, Coghlan MP, Sloop KW. A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity · Diabetes (2025) · PMID 40521890
  32. Wang L, Wang N, Zhang W et al.. Therapeutic peptides: current applications and future directions · Signal Transduct Target Ther (2022) · PMID 35165272

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Important safety information

+

Possible side effects

• Nausea
• Diarrhea or constipation
• Fatigue
• Reduced appetite
• Heartburn

Do not use if you have

• Active cancer or history of cancer (unless approved by oncologist)
• Pregnancy or breastfeeding
• Severe kidney or liver disease
• Known allergy to the peptide or excipients
• Medullary thyroid cancer history
• MEN 2 syndrome

If you experience severe side effects, call 911 or go to your nearest emergency room.

How supplied

dose-specific vials (Tirzepatide / Glycine): 2.5mg → 10 mg per 2 mL vial (5 mg/mL) + glycine; 5mg → 20 mg per 2 mL vial (10 mg/mL) + glycine; 7.5mg → 30 mg per 2 mL vial (15 mg/mL) + glycine; 10mg → 40 mg per 2 mL vial (20 mg/mL) + glycine; 12.5mg → 50 mg per 2 mL vial (25 mg/mL) + glycine; 15mg → 60 mg per 2 mL vial (30 mg/mL) + glycine

Common questions

Frequently asked
about Tirzepatide (Injectable).

Mounjaro (diabetes) and Zepbound (weight loss) are Eli Lilly brand-name, FDA-approved products. Our compounded tirzepatide is prepared by an FDA-registered 503A pharmacy and is not FDA-approved — the FDA does not review compounded drugs for safety, effectiveness, or quality. A licensed physician decides whether it's appropriate for you.

35 more questions about Pepti, answered.

Yes. Tirzepatide is one of the medications Pepti requires recent bloodwork for before it is prescribed. Upload a recent lab report from any lab, or order Pepti's at-home panel; the physician reviews the results with your assessment.

Read next

Questions people ask
about Tirzepatide (Injectable).

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Pharmacy network accreditation

PCAB-accredited pharmacies on every order.

Every fulfillment runs through a PCAB-accredited pharmacy.

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PCAB — Pharmacy Compounding Accreditation Board · Accredited
  • Rigorous third-party quality & safety inspections
  • Cleanliness and sterile processes
  • Proper ingredient sourcing
  • Accurate dosing and formulation
  • Staff training and procedures
  • Accredited by NABP & ACHC