
Semax (Injectable)
Cognitive enhancement
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
Semax (Injectable)
A neuropeptide that enhances BDNF expression, supporting memory, focus, and cognitive performance.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
- Lot 102626-SEA-1
Tested 2026-10-28 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.9%
- Lot 102626-SEA-2
Tested 2026-10-28 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.1%
- Lot 101926-SEA-1
Tested 2026-10-21 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.7%
How Semax is prescribed.
- Adults who feel foggy, distracted or mentally tired
- Professionals who want sharper focus without a stimulant
- People who want a brain peptide as part of a longevity protocol
- Patients pairing it with Selank for focus plus calm
Your physician decides whether Semax is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of Semax.
Everything published
about Semax.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How Semax works, and what the research shows.
Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) by up to 3x.
It enhances memory consolidation, neuroprotection, and overall cognitive performance.
References
- Dolotov OV, Karpenko EA, Inozemtseva LS et al.. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus · Brain Res (2006) · PMID 16996037
- Dmitrieva VG, Povarova OV, Skvortsova VI et al.. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia · Cell Mol Neurobiol (2010) · PMID 19633950
- Medvedeva EV, Dmitrieva VG, Povarova OV et al.. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis · BMC Genomics (2014) · PMID 24661604
- Inozemtseva LS, Yatsenko KA, Glazova NY et al.. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress · Eur J Pharmacol (2024) · PMID 39442746
- Gusev EI, Skvortsova VI, Miasoedov NF et al.. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)] · Zh Nevrol Psikhiatr Im S S Korsakova (1997) · PMID 11517472
- Miasoedova NF, Skvortsova VI, Nasonov EL et al.. [Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke] · Zh Nevrol Psikhiatr Im S S Korsakova (1999) · PMID 10358912
- Gusev EI, Skvortsova VI, Chukanova EI. [Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency] · Zh Nevrol Psikhiatr Im S S Korsakova (2005) · PMID 15792140
- Gusev EI, Martynov MY, Kostenko EV et al.. [The efficacy of semax in the treatment of patients at different stages of ischemic stroke] · Zh Nevrol Psikhiatr Im S S Korsakova (2018) · PMID 29798983
- Polunin GS, Nurieva SM, Baiandin DL et al.. [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease] · Vestn Oftalmol (2000) · PMID 10741256
- Kurysheva NI, Shpak AA, Ioileva EE et al.. [Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone] · Vestn Oftalmol (2001) · PMID 11569188
- Lebedeva IS, Panikratova YR, Sokolov OY et al.. Effects of Semax on the Default Mode Network of the Brain · Bull Exp Biol Med (2018) · PMID 30225715
- Tsai SJ. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome · Med Hypotheses (2007) · PMID 16996699
- Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN et al.. Placebos without deception: a randomized controlled trial in irritable bowel syndrome · PLoS One (2010) · PMID 21203519
- Panikratova YR, Lebedeva IS, Sokolov OY et al.. Functional Connectomic Approach to Studying Selank and Semax Effects · Dokl Biol Sci (2020) · PMID 32342318
- Eremin KO, Kudrin VS, Saransaari P et al.. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents · Neurochem Res (2005) · PMID 16362768
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
5 mL multi-dose vial, Semax 2 mg/mL (10 mg Semax per vial)
Frequently asked
about Semax (Injectable).
A neuropeptide that enhances BDNF expression, supporting memory, focus, and cognitive performance. Semax is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
Semax is $229 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
Semax is commonly prescribed for: Adults who feel foggy, distracted or mentally tired; Professionals who want sharper focus without a stimulant; People who want a brain peptide as part of a longevity protocol; Patients pairing it with Selank for focus plus calm. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. Semax is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. Semax can be prescribed from the assessment alone. If your physician wants labs for your care, they'll ask through your account; upload a recent lab report from any lab at no charge, or order Pepti's at-home panel.
Semax is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
32 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $229 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded Semax with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of Semax are usually mild: mild nasal irritation (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and Semax is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add Semax to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded Semax is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only Semax sold without a prescription is labeled not for human use and is a different product.
Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) by up to 3x. At Pepti it is prescribed to support memory support, neuroprotection, mental performance, bdnf boost. Individual response varies, and your physician sets expectations at approval.
Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) by up to 3x. It enhances memory consolidation, neuroprotection, and overall cognitive performance. Compounded Semax is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
Semax is prescribed for memory support, neuroprotection, mental performance, bdnf boost. It is commonly requested by adults who feel foggy, distracted or mentally tired; Professionals who want sharper focus without a stimulant; people who want a brain peptide as part of a longevity protocol; patients pairing it with Selank for focus plus calm. Whether it is appropriate for you is the reviewing physician's decision.
Semax is studied for memory support, neuroprotection, mental performance, bdnf boost. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Semax is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules Semax out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate Semax is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $229 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg Semax. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. Semax ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$229 per month covers the compounded Semax, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. Semax is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
Semax ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$229 per month at Pepti. That includes the compounded Semax, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies Semax as a monthly injectable vial with syringes and prep pads included, one vial per month at $229, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes Semax online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $229 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then Semax ships from the pharmacy. No clinic visit and no video appointment in most cases. $229 per month, all-in.
Yes, for the real thing. Semax sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's Semax is physician-prescribed, pharmacy-compounded, batch-tested, and $229 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $229 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed Semax online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded Semax is not FDA-approved.
$229 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and Semax ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose Semax, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, Semax ships within 1-3 business days and arrives in 1-3 more; if not, the $229 is refunded.
No. Semax can be prescribed from the assessment alone at Pepti. If your physician wants labs for your care, they'll ask through your account; upload a lab report from any lab, or order a Pepti at-home panel from $129.
Pepti ships Semax to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about Semax (Injectable).
- Semax: What It Is, Where to Get It Prescribed, and What It CostsSemax — 5 mL multi-dose vial, Semax 2 mg/mL (10 mg Semax per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Dihexa vs Semax: Mechanism, Evidence, Cost, and Which One FitsDihexa and Semax are both prescribed for memory and focus, but they come from different systems and have very different evidence. A side-by-side of what each is, how each is described to work, the human data, FDA status, dosing, price and who suits which.
- Semax Dosage: How Pepti Prescribes the Injection, in Units, mL and mgThe Semax peptide dosing Pepti prescribes: 0.25 mL (25 units on a U-100 insulin syringe) under the skin once daily Monday through Friday, 0.5 mg per dose, 20 doses per vial. Includes a Semax dosage chart in units, mL and mg, the blends that contain Semax, timing, what the Russian studies used, and side effects.
- Semax Side Effects: What Is Reported, What to Watch, and Who Should Not Take ItA practical reference to Semax injection side effects: injection-site reactions, restlessness with late-day doses, early headache, the stimulant question, what the FDA's 2026 review said about safety, what needs urgent care, and who should discuss it first.
- Semax Benefits: What the Research Actually ShowsThe benefits claimed for the Semax peptide, one at a time: focus and memory, BDNF, neuroprotection after stroke, chronic cerebrovascular disease, the optic nerve, stress and mood, migraine and ADHD, each labelled as animal or human research, with an honest strength-of-evidence rating.
- Can You Take Semax With Tirzepatide or Semaglutide?Semax and tirzepatide or semaglutide act on unrelated systems, and some people are prescribed both. What each one does, what is and is not known about taking them together, which Semax blends change the picture, how to tell their side effects apart, and how to add Semax properly.
- How Long Does Semax Take to Work? What the Studies Measured, and WhenThere is no trial-established timeline for Semax in healthy adults. This page sets out what each Semax study measured and how long it ran, from single-dose rat and brain-imaging work to Russian stroke studies, why none of it gives a date, and what to track on the weekday injection.
- Do You Need a Prescription for Semax? Is It Legal to Buy Online?Yes: injectable Semax is a prescription medication in the US. What the law says, where Semax stands with the FDA after the 2026 Category 2 removal and July advisory vote, what "research use only" means, and what Pepti's vial costs.
- Best Place to Get Semax Online: How to Choose a PrescriberThe best place to get Semax online is a telehealth provider with a physician licensed in your state, a named licensed 503A pharmacy, published lot testing and one all-in price. A checklist for choosing a provider, the questions to ask, and what Pepti offers.
- Semax for Women: What the Research Has Looked At, and What to Check FirstWhat research has actually studied about Semax in women (no female-specific study exists), why the ACTH fragment is not expected to raise cortisol or act on estrogen, the thyroid, iron and perimenopause causes of brain fog worth ruling out first, pregnancy, birth control and hormone therapy, stimulant medication, and how to get Semax prescribed.
- Semax for Men: What the Research Has Looked At, and What to Check FirstWhat research has actually studied about Semax in men (no male-specific human study; one male-rat stress study), why the ACTH fragment is not expected to raise cortisol or act on testosterone, stimulant medication, the causes of poor focus worth ruling out first, fertility, sport, and how to get Semax prescribed.
- Is Semax Banned in Sports? WADA Status, the ACTH Question and Drug TestsSemax is not named on the 2026 WADA Prohibited List, but it is built from a fragment of ACTH, and corticotrophins are listed at S2.2.2. What tested athletes should ask, why blends with Semax are a different answer, and why a workplace drug screen does not look for it.
- Peptides for Brain Fog and Focus: What Is Prescribed, and What WorksThe peptides used for brain fog and focus, what each one does in the brain, how they are taken, what they cost, and the medical causes worth ruling out first.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- How to get Semax prescribed online
- How Much Does Semax (Injectable) Cost?Semax (Injectable) cost in 2026: $229 per month all-in at Pepti — compounded medication, physician review, and shipping included. No membership or consult fees.
Read more about Semax (Injectable).
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