Ipamorelin + Sermorelin Dosage: Units, mL and mg for the IPA Sermorelin Vial

Every price is all-in, covering medication, physician review, refill management and shipping, with no separate membership fee. Pepti is cash-pay and does not bill insurance. These are the typical printed directions; your own directions are the ones on your vial.

Directions are written in two forms, millilitres and units, because prescriptions are written in millilitres and insulin syringes are marked in units. On a U-100 insulin syringe, 1 unit is 0.01 mL, so 25 units is 0.25 mL. A unit is a volume mark on the barrel, not a measure of strength. In a two-peptide vial, one volume carries two medications, and the amount of each comes from its own concentration on the label.

Online sources often quote both peptides in micrograms. 1 mg is 1,000 mcg, so 0.5 mg and 500 mcg are the same amount; confusing the two is a thousandfold error. A vial labelled 10 mg of each is not a 10 mg dose of anything: it is twenty doses of 0.5 mg of each. If your label and your syringe seem to disagree, do not dose; message your care team. How long does a peptide vial last explains every number on a vial label.

The chart below is the conversion for Pepti's vial, with both peptides at 2 mg/mL, drawn with a U-100 insulin syringe. It is math only. It is not a menu of doses, and the only line that applies to you is the one that matches the number printed on your vial.

The rule behind every row: units divided by 100 gives millilitres, and millilitres multiplied by 2 gives milligrams of each peptide. Because both are at the same concentration, the two columns are always identical. A chart written for a different vial, or for a single-peptide vial, gives different figures for the same units, which is the main reason not to dose from a chart, including this one.

Why the units do not carry over between ipamorelin products

The same 25 unit draw delivers different amounts of ipamorelin depending on the vial. From the single ipamorelin vial at 1 mg/mL it is 0.25 mg; from Ipamorelin + Sermorelin at 2 mg/mL it is 0.5 mg; from CJC-1295 / Ipamorelin at 2.4 mg/mL it is 0.6 mg. The sermorelin side is simpler: the single sermorelin vial and the paired vial are both 2 mg/mL, so 25 units is 0.5 mg of sermorelin from either. If you switch products, read the new label and never carry a number over. More on ipamorelin across the catalogue is in ipamorelin dosage, and the single-peptide sermorelin vial is in sermorelin dosage.

Four weeks is why refills run every 28 days, one vial per fill. Vials are multi-dose solutions shipped ready to use, refrigerated with ice packs, with sterile syringes and alcohol prep pads. Nothing is mixed at home. Keep the vial in the fridge between doses and follow the beyond-use date on the label, which runs from first puncture; how to store peptides covers storage. Ipamorelin + Sermorelin is a vial only, with no pen.

If a vial runs short before the refill, message your care team rather than adjusting anything yourself. If you miss a dose, follow your directions and do not take two doses to make up for one.

At bedtime

Growth hormone is released in pulses, and the largest natural pulse of the day occurs in the first hours of deep sleep. Both peptides prompt the pituitary to release its own growth hormone in a short pulse. Sermorelin acts at the GHRH receptor, and in a 1997 trial of a GHRH(1-29) analogue the pulse appeared within about ten minutes and lasted about two hours. Ipamorelin acts at the ghrelin receptor, and in a 1999 volunteer study its pulse peaked at about 40 minutes and faded to negligible levels. A bedtime dose places both alongside the pulse the body is already producing.

Monday through Friday

The five-nights-on, two-off pattern is a prescriber convention rather than a schedule derived from trials. Prescribers describe the two nights off as a way of keeping the pituitary responsive. It also makes the vial arithmetic exact: 20 doses at five a week is four weeks. Weekends off are part of the schedule, not missed doses.

Technique is covered in how to inject peptides safely.

No study has tested ipamorelin and sermorelin together, at any dose. The studies on each component are often quoted online as if they were adult protocols:

There is no human study of subcutaneous ipamorelin, no human dose-ranging study behind the adult sermorelin schedules in common use, and no study of the pair. A 1995 study in eight healthy men gave GHRH(1-29) and a different ghrelin-receptor peptide, GHRP-2, separately and together, and reported a roughly additive response with no synergy; whether this pairing behaves that way at nightly subcutaneous doses has not been tested. That is why your directions come from a physician who has reviewed your intake, not from a study table. The full background is in what is ipamorelin + sermorelin.

When directions change, the new numbers are printed on the new label. Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account.

Growth hormone reduces insulin sensitivity, so diabetes or impaired glucose tolerance needs raising at intake, and a cancer history is a reason to discuss rather than proceed. The fuller picture is in is sermorelin safe. Tested athletes should know the 2026 WADA Prohibited List names both sermorelin and ipamorelin under S2.2.4, prohibited at all times.

On regulation: sermorelin was the active ingredient of an FDA-approved product discontinued in 2008 for commercial reasons, and in 2013 the FDA determined it was not withdrawn for safety or effectiveness reasons. Ipamorelin has never been approved; it was placed in Category 2 in 2023, the advisory committee voted 0 to 12 against listing it in October 2024, and its 503A nomination has since been withdrawn, so as of May 2026 it sits in no 503A category while remaining in Category 2 under the separate 503B policy. Compounded medications are not FDA approved.

Ipamorelin + Sermorelin cannot be bought legitimately without a prescription. Sites selling it "for research use only" are not accountable for identity, purity, sterility or concentration, so even the concentration a units chart depends on is unknown. The prescription route:

1. Complete a free online intake covering your history, medications and what you want help with.
2. A physician licensed in your state reviews it, usually within 24 hours.
3. If it is appropriate, a PCAB-accredited, FDA-registered US 503A compounding pharmacy prepares it to that prescription. Lot test results are published at /quality/lab-results.
4. It ships refrigerated with your directions printed on the vial.
5. Your physician stays reachable for questions and dose changes.

Pepti prescribes Ipamorelin + Sermorelin in every state except Oklahoma, plus DC Sermorelin alone has a step-by-step page at how to get sermorelin prescribed online, and the same intake covers the paired vial. Comparisons: sermorelin vs tesamorelin vs ipamorelin and CJC-1295 vs sermorelin.