NAD+ vs Glutathione: Which One, What Each Does, Evidence, Dosing and Cost

Every figure is an all-in monthly price covering the medication, physician review, refill management and shipping. There is no separate membership fee, and Pepti is cash-pay and does not bill insurance. Current pricing always lives on each product page.

The link is real biochemistry, not marketing. When glutathione neutralizes a reactive molecule it is oxidized, and glutathione reductase recycles it back to the active form using NADPH, the phosphorylated form of NAD. So the NAD system supplies the reducing power that keeps glutathione working, and glutathione does the antioxidant work itself. That connection is the reason prescribers often pair them. It is a mechanism argument: no study has tested whether injecting NAD+ changes glutathione levels in people, or whether the two together do more than either alone.

Same total, different jobs

The vials happen to hold the same 1,000 mg and deliver almost the same amount per dose, but that says nothing about strength. They are different molecules doing different work, and milligram for milligram comparisons between them are meaningless. The useful question is which job you and your physician are trying to support.

Both are in the same category, and neither was involved in the 2026 peptide changes:

The two alerts are the clearest reason to get either from an accountable pharmacy. Compounded medications are not FDA approved, and neither compounded NAD+ nor compounded glutathione is an FDA-approved drug product. Pepti's lot test results are at /quality/lab-results.

Both are injected under the skin into the abdomen or thigh, rotating sites, three times a week. Both come as multi-dose solutions shipped ready to use, refrigerated with ice packs, with sterile syringes and alcohol prep pads.

On a U-100 insulin syringe, 1 unit is 0.01 mL. The milligram figures are arithmetic for reading a label, not a way to set a dose. Your physician sets your directions after reviewing your intake, and your exact dose is printed on the vial. The subcutaneous doses are a small fraction of the gram-level intravenous doses in the published glutathione trials, which is one reason those findings should not be assumed to transfer. Refills run every 28 days, one vial per fill. More is in NAD+ injection dosage and glutathione dosage.

NAD+. Flushing, warmth, tightness in the chest or abdomen, or nausea during the injection, fading within minutes, mostly driven by injection speed. Stinging at the site is common because the solution is acidic. Some people feel wired if they dose late in the day. The full picture is in is NAD+ safe.

Glutathione. Mostly injection-site redness, mild soreness or bruising, and in some people brief lightheadedness or nausea after a dose. The intravenous Parkinson's trial at far higher doses reported adverse events similar to placebo. Mention asthma, because inhaled glutathione has been reported to provoke bronchospasm. More is in glutathione side effects.

For both. Fever, chills, shaking or vomiting after a dose are not expected reactions; they are what the endotoxin alerts described. Message your care team the same day. Facial or throat swelling, a widespread rash or difficulty breathing is an emergency: call 911 first, then tell your physician.

The biochemistry of both molecules is textbook and not in question. What is thin is the clinical layer for the route Pepti uses. NAD+ has oral precursor trials and one intravenous pilot; glutathione has oral, intravenous, intranasal and topical trials, with mixed results. Neither has a randomized trial of subcutaneous injection, and neither has been shown to treat any disease by that route. Claims that either "detoxes" the body in the marketing sense, reverses aging or lightens skin by injection are ahead of the evidence. What is fair: both are molecules the body already uses, both are reported as well tolerated, and both have a real research base by other routes.

Neither can be bought legitimately as an injection without a prescription. Products sold "for research use only" are not accountable for identity, purity, sterility or concentration, and for both molecules the FDA has specifically warned about contaminated ingredients. The prescription route:

1. Complete a free online intake covering your history, medications and what you want help with.
2. A physician licensed in your state reviews it, usually within 24 hours.
3. If it is appropriate, a PCAB-accredited, FDA-registered US 503A compounding pharmacy prepares it to that prescription. Lot test results are published at /quality/lab-results.
4. It ships refrigerated with ice packs and your directions printed on the vial.
5. Your physician stays reachable for questions and dose changes.

Pepti prescribes both in every state except Oklahoma, plus DC Step by step: how to get NAD+ prescribed online and how to get glutathione prescribed online.