Methylcobalamin (Active B12) (Injectable)
Active B12 for energy & cognition
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
Methylcobalamin (Active B12) (Injectable)
Methylcobalamin is the most active and bioavailable form of vitamin B12 — far more effective than oral B12 supplements. Supports energy, cognitive function, and nerve health. Weekly self-injection.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
Checks the active peptide against impurities and degradation products.
Confirms the peptide in the vial is the correct molecule.
Confirms the solution sits within the range specified for injection.
Checks the finished vial for visible and sub-visible particles.
Confirms the vial seal holds so sterility is maintained through the beyond-use date.
How Methylcobalamin is prescribed.
- Adults who feel tired all the time and want to rule out low B12
- People on metformin, acid reducers or a plant-based diet, which all lower B12
- Anyone with tingling or numbness their physician has linked to B12
- Patients who want the active form rather than the cheaper cyanocobalamin
Your physician decides whether Methylcobalamin is appropriate for you after reviewing your intake and labs.
Inject 1.25 mL (125 units) intramuscularly once weekly.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of Methylcobalamin.
Everything published
about Methylcobalamin (Active B12).
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How Methylcobalamin works, and what the research shows.
Methylcobalamin is the active form of vitamin B12 your body uses directly, needed for energy production, red blood cells and the coating on nerves.
As a weekly injection it bypasses the gut entirely.
B12 injection is standard care for deficiency.
In people with normal levels the energy effect is modest and is reported mostly by those who were running low.
References
- Stabler SP. Clinical practice. Vitamin B12 deficiency · N Engl J Med (2013) · PMID 23301732
- Devalia V, Hamilton MS, Molloy AM. Guidelines for the diagnosis and treatment of cobalamin and folate disorders · Br J Haematol (2014) · PMID 24942828
- Wolffenbuttel BHR, Wouters HJCM, Heiner-Fokkema MR, van der Klauw MM. The Many Faces of Cobalamin (Vitamin B12) Deficiency · Mayo Clin Proc Innov Qual Outcomes (2019) · PMID 31193945
- Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin · Blood (1998) · PMID 9694707
- Obeid R, Fedosov SN, Nexo E. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency · Mol Nutr Food Res (2015) · PMID 25820384
- Aroda VR, Edelstein SL, Goldberg RB, et al.. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study · J Clin Endocrinol Metab (2016) · PMID 26900641
- Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B12 deficiency among vegetarians? · Nutr Rev (2013) · PMID 23356638
- Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature · Eur J Clin Nutr (2014) · PMID 24667752
- Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness · Br J Nutr (1973) · PMID 4583554
- Mandra EV, Parfenov VA, Stupin VA, Silina EV. Vitamin B Supplementation for Diabetic Peripheral Neuropathy: A Review and Meta-Analysis · J Clin Med (2026) · PMID 42452619
- Vaucher P, Druais PL, Waldvogel S, Favrat B. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial · CMAJ (2012) · PMID 22777991
- Stuber MJ, Moutzouri E, Feller M, et al.. Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial · The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences (2020) · PMID 32577745
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
vial — Methylcobalamin B12 10mg/5mL 2mg/mL (5mL)
Frequently asked
about Methylcobalamin (Active B12) (Injectable).
Methylcobalamin is the most active and bioavailable form of vitamin B12 — far more effective than oral B12 supplements. Supports energy, cognitive function, and nerve health. Weekly self-injection. Methylcobalamin (Active B12) is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
Methylcobalamin (Active B12) is $229 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
Methylcobalamin (Active B12) is commonly prescribed for: Adults who feel tired all the time and want to rule out low B12; People on metformin, acid reducers or a plant-based diet, which all lower B12; Anyone with tingling or numbness their physician has linked to B12; Patients who want the active form rather than the cheaper cyanocobalamin. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. Methylcobalamin (Active B12) is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. Methylcobalamin (Active B12) can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
Methylcobalamin (Active B12) is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
33 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $229 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded Methylcobalamin (Active B12) with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of Methylcobalamin (Active B12) are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and Methylcobalamin (Active B12) is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Any dose change is made by your physician from the chart, without an appointment. Message them through your account if you think your dose should change.
Yes. Add Methylcobalamin (Active B12) to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded Methylcobalamin (Active B12) is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only Methylcobalamin (Active B12) sold without a prescription is labeled not for human use and is a different product.
Methylcobalamin is the active form of vitamin B12 your body uses directly, needed for energy production, red blood cells and the coating on nerves. At Pepti it is prescribed to support most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. Individual response varies, and your physician sets expectations at approval.
Methylcobalamin is the active form of vitamin B12 your body uses directly, needed for energy production, red blood cells and the coating on nerves. As a weekly injection it bypasses the gut entirely. Compounded Methylcobalamin (Active B12) is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
Methylcobalamin (Active B12) is prescribed for most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. It is commonly requested by adults who feel tired all the time and want to rule out low B12; people on metformin, acid reducers or a plant-based diet, which all lower B12; Anyone with tingling or numbness their physician has linked to B12; patients who want the active form rather than the cheaper cyanocobalamin. Whether it is appropriate for you is the reviewing physician's decision.
Methylcobalamin (Active B12) is studied for most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
B12 injection is standard care for deficiency. In people with normal levels the energy effect is modest and is reported mostly by those who were running low. References are listed on this page.
Methylcobalamin (Active B12) is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules Methylcobalamin (Active B12) out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate Methylcobalamin (Active B12) is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $229 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg Methylcobalamin (B12). One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. Methylcobalamin (Active B12) ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$229 per month covers the compounded Methylcobalamin (Active B12), the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. Methylcobalamin (Active B12) is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
Methylcobalamin (Active B12) ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$229 per month at Pepti. That includes the compounded Methylcobalamin (Active B12), the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies Methylcobalamin (Active B12) as a monthly injectable vial with syringes and prep pads included, one vial per month at $229, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes Methylcobalamin (Active B12) online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $229 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then Methylcobalamin (Active B12) ships from the pharmacy. No clinic visit and no video appointment in most cases. $229 per month, all-in.
Yes, for the real thing. Methylcobalamin (Active B12) sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's Methylcobalamin (Active B12) is physician-prescribed, pharmacy-compounded, batch-tested, and $229 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $229 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed Methylcobalamin (Active B12) online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded Methylcobalamin (Active B12) is not FDA-approved.
$229 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and Methylcobalamin (Active B12) ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose Methylcobalamin (Active B12), and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, Methylcobalamin (Active B12) ships within 1-3 business days and arrives in 1-3 more; if not, the $229 is refunded.
No. Methylcobalamin (Active B12) can be prescribed from the assessment alone at Pepti. Bloodwork is required only for GLP-1s and growth-hormone secretagogues.
Pepti ships Methylcobalamin (Active B12) to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about Methylcobalamin (Active B12) (Injectable).
- Methylcobalamin (Active B12): What It Is, Where to Get It Prescribed, and What It CostsMethylcobalamin (Active B12) — vial — Methylcobalamin B12 10mg/5mL 2mg/mL (5mL). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Peptides for Energy and Fatigue: What Is Prescribed and What to Rule OutNAD+, MOTS-c, SS-31 and the injectable nutrients used for fatigue: what each one is, how it is given, what it costs, and the causes a physician must exclude first.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- Do You Need a Doctor to Get Peptides? Yes, and Here Is Exactly WhyPeptides used clinically are prescription medications. Why a prescriber is legally required, what your own doctor will likely say, and what a real review looks like online.
- How to Inject Peptides Safely: Step by Step, Units, Sites and MistakesA practical subcutaneous injection walkthrough: reading your sig, converting millilitres to insulin-syringe units, the ten steps, site rotation, what to do about bubbles and missed doses.
Read more about Methylcobalamin (Active B12) (Injectable).
Ready to start with Methylcobalamin (Active B12) (Injectable)?
Free assessment. Licensed physicians. Money-back guarantee if not approved.
In your pocket.
Message your medical team, track every order, chart every lab marker. 5.0 on the App Store.
Get the app
PCAB-accredited pharmacies on every order.
Every fulfillment runs through a PCAB-accredited pharmacy.
See the lab results
- Rigorous third-party quality & safety inspections
- Cleanliness and sterile processes
- Proper ingredient sourcing
- Accurate dosing and formulation
- Staff training and procedures
- Accredited by NABP & ACHC