Anti-Aging · Reference
Hexarelin Dosage: How Pepti Prescribes It, in Units, mL and mg
This page explains the hexarelin dosage Pepti prescribes, what the units on the syringe mean, a conversion chart for the vial, why the schedule is bedtime and weekdays only, what the published studies used and why that is not your dose, and what can change your directions. It covers how Pepti prescribes hexarelin, not online protocols. Nothing here is a reason to change your own dose.
At Pepti, hexarelin is prescribed as 0.25 mL, which is 25 units on a U-100 insulin syringe, injected under the skin Monday through Friday nights at bedtime. The 5 mL vial holds 12.5 mg at 2.5 mg/mL, so every 0.25 mL dose delivers 0.625 mg of hexarelin, and the vial holds 20 doses, about four weeks. The two nights off each week reflect the human desensitisation data: continuous dosing turned the growth hormone response down, intermittent dosing did not. Your physician sets your directions after reviewing your intake, and your exact dose and units are printed on the vial.
This page explains the hexarelin dosage Pepti prescribes, what the units on the syringe mean, a conversion chart for the vial, why the schedule is bedtime and weekdays only, what the published studies used and why that is not your dose, and what can change your directions. It covers how Pepti prescribes hexarelin, not online protocols. Nothing here is a reason to change your own dose.
Hexarelin Dosage
The short answer
| Product | Vial | Directions | Per dose | Doses per vial | Price |
|---|---|---|---|---|---|
| Hexarelin | 5 mL multi-dose vial, 2.5 mg/mL (12.5 mg per vial) | Inject 0.25 mL (25 units) subcutaneously Monday through Friday nights at bedtime | 0.625 mg | 20 | $209/mo |
The price is all-in, covering medication, physician review, refill management and shipping, with no separate membership fee. Pepti is cash-pay and does not bill insurance. Your own directions are the ones printed on your vial.
Hexarelin Dosage
Hexarelin dosage in units, mL and mg
Pepti's directions are written in millilitres and units, because prescriptions are written in millilitres and insulin syringes are marked in units. On a U-100 insulin syringe, 1 unit is 0.01 mL, so 100 units is 1 mL and 25 units is 0.25 mL. A unit is a volume mark on the barrel, not a measure of how strong the medication is.
The milligrams come from the vial's concentration. Hexarelin is supplied at 2.5 mg/mL, so:
| Step | Value |
|---|---|
| Concentration | 2.5 mg/mL (12.5 mg in 5 mL) |
| Printed volume | 0.25 mL |
| Syringe mark | 25 units on a U-100 insulin syringe |
| Arithmetic | 0.25 mL multiplied by 2.5 mg/mL |
| Hexarelin per dose | 0.625 mg (625 micrograms) |
That arithmetic is a way to read a label, not a way to set a dose. A vial labelled 12.5 mg is not a 12.5 mg dose: it is twenty doses of 0.625 mg. If your label and your syringe seem to disagree, do not dose; message your care team. How long does a peptide vial last explains every number on a vial label.
Hexarelin Dosage
Hexarelin dosage chart: units to mL to mg
The chart below is the conversion for a 2.5 mg/mL hexarelin vial, drawn with a U-100 insulin syringe. It is math only. It is not a menu of doses, and the only line that applies to you is the one that matches the number printed on your vial.
| Syringe mark (U-100) | Volume | Hexarelin |
|---|---|---|
| 5 units | 0.05 mL | 0.125 mg |
| 10 units | 0.1 mL | 0.25 mg |
| 15 units | 0.15 mL | 0.375 mg |
| 20 units | 0.2 mL | 0.5 mg |
| 25 units (Pepti's typical directions) | 0.25 mL | 0.625 mg |
| 50 units | 0.5 mL | 1.25 mg |
| 100 units | 1 mL | 2.5 mg |
The rule behind every row: units divided by 100 gives millilitres, and millilitres multiplied by 2.5 gives milligrams. That multiplier only holds for a 2.5 mg/mL vial. A chart written for a different concentration gives different milligram figures for the same units, which is the main reason not to dose from a chart, including this one.
Hexarelin Dosage
When hexarelin is taken
At bedtime
Growth hormone is released mainly in the first hours of deep sleep. A bedtime injection lands the hexarelin pulse on top of that natural nocturnal release rather than after a meal, and a 2000 paper in Hormone and Metabolic Research described food intake modulating the response. The pharmacology says what happens after a dose: a growth hormone pulse within the hour, with a smaller and shorter rise in cortisol and prolactin alongside it, gone by morning.
Monday through Friday, with two nights off
This is the part of the schedule that rests most directly on human data. In a sixteen-week study in the Journal of Clinical Endocrinology and Metabolism in 1998, healthy elderly volunteers took twice-daily subcutaneous hexarelin, and the growth hormone response to a test dose fell by about a third by week one and by nearly half by week sixteen, returning to baseline four weeks after stopping. Two shorter studies in older adults in the European Journal of Endocrinology in 1996, using intermittent intranasal or oral dosing for eight and fifteen days, found no desensitisation. The weekend break is the practical answer to that pattern. It is part of the schedule, not two missed doses.
Under the skin, and where
Subcutaneous means into the fat layer, not the muscle. The founding 1994 volunteer study reported that the subcutaneous route delivered 77 per cent of the intravenous response. Abdomen and thigh are the usual sites, rotated so the same spot is not used repeatedly. Technique is covered in how to inject peptides safely.
Directions say What it means in practice 0.25 mL (25 units) Draw to the 25 mark on a U-100 insulin syringe Subcutaneously Into the fat layer, abdomen or thigh, rotating sites Nights at bedtime One injection shortly before sleep Monday through Friday Five doses a week, weekends off 20 doses per vial About four weeks
Hexarelin Dosage
How long a hexarelin vial lasts, storage and refills
| Step | Value |
|---|---|
| Dose | 25 units, 0.25 mL, 0.625 mg |
| Doses per week | 5 (Monday through Friday) |
| Doses per vial | 20 (5 mL divided by 0.25 mL) |
| Used over the vial | 12.5 mg, the whole vial |
| Time per vial | 20 doses divided by 5 per week = 4 weeks |
Vials are multi-dose solutions shipped ready to use, refrigerated with ice packs, with sterile syringes and alcohol prep pads. Nothing is mixed at home. Keep the vial in the fridge and follow the beyond-use date on the label, which runs from first puncture. Cloudiness, particles or a change from what you received is a reason to message rather than inject. One vial per fill, and refills run every 28 days. How to store peptides covers storage.
If a vial runs short, message your care team rather than adjusting anything yourself. If you miss a night, follow your directions and do not take two doses to make up for one.
Hexarelin Dosage
What the studies used, and why that is not your dose
Hexarelin has more human pharmacology on record than almost any other compounded peptide, almost all of it from 1994 to 2003. Almost none of it was designed around the way hexarelin is prescribed today.
| Study | Who | Route and schedule | What it was for |
|---|---|---|---|
| Journal of Clinical Endocrinology and Metabolism, 1994 | Twelve healthy young volunteers | Single doses by four routes: intravenous, subcutaneous, intranasal, oral | Comparing routes; subcutaneous delivered 77 per cent of the intravenous response |
| European Journal of Endocrinology, 2002 | Six young men | Two or three subcutaneous injections across one day | 24-hour growth hormone secretion; pulses enlarged, frequency unchanged |
| Journal of Clinical Endocrinology and Metabolism, 1998 | Healthy elderly volunteers | Twice-daily subcutaneous for sixteen weeks | Desensitisation; body composition did not change |
| European Journal of Endocrinology, 1996 | Older adults | Intermittent intranasal or oral for eight and fifteen days | No desensitisation on intermittent dosing |
| Clinical Endocrinology, 1995, and European Journal of Endocrinology, 1996 | Eight and seven short children | Intranasal, three times daily, six to ten months | Open-label growth studies |
| Turin cardiac studies, 1999 and 2002 | Volunteers and cardiac patients | Single intravenous doses | Short-lived rise in ejection fraction |
Many of these were diagnostic or research uses: single doses to probe the growth hormone axis, or tests of pituitary reserve. The sustained courses were intranasal in children or twice daily in older adults. None tested a nightly subcutaneous schedule with weekends off, and none measured sleep, recovery or wellbeing. So the directions on your vial are a prescribing standard informed by that pharmacology, not a dose a trial established. The full research picture is in what is hexarelin.
Hexarelin Dosage
Hexarelin next to the other growth hormone peptides
People sometimes compare a hexarelin dose with other growth hormone peptides. The draw can look the same, but the products are not interchangeable:
| Hexarelin | Ipamorelin | Sermorelin | CJC-1295 / Ipamorelin | |
|---|---|---|---|---|
| Vial | 12.5 mg in 5 mL (2.5 mg/mL) | 5 mg in 5 mL (1 mg/mL) | 10 mg in 5 mL (2 mg/mL) | 6 mg CJC-1295 and 12 mg ipamorelin in 5 mL |
| Receptor | Ghrelin receptor (GHS-R1a), plus CD36 | Ghrelin receptor | GHRH receptor | GHRH receptor and ghrelin receptor |
| Price | $209/mo | $239/mo | $229/mo | $239/mo |
A milligram of hexarelin is not a milligram of ipamorelin, and each product's directions are its own, printed on its own vial. The comparisons are in ipamorelin vs hexarelin, sermorelin vs hexarelin and CJC-1295 vs hexarelin.
Hexarelin Dosage
What changes the directions
Your physician sets your directions after reviewing your intake. Things that can lead to different directions, or a different product, include:
| What can change | How it shows up |
|---|---|
| Whether hexarelin is the right product | A long course with the cleanest hormonal profile may point to ipamorelin; the GHRH half as well to CJC-1295 / Ipamorelin |
| Diabetes or impaired glucose tolerance | Anything raising growth hormone can raise glucose; raised at intake |
| A history of cancer | A theoretical concern with anything raising growth hormone and IGF-1; raised at intake |
| A condition sensitive to cortisol or prolactin | Hexarelin raises both briefly with each dose |
| A cardiac diagnosis | A single dose raised heart contractility in every human study that looked |
| Pregnancy or breastfeeding | Not used; safety data is absent |
| How you respond | Reactions you report go to your physician, who may revise your directions |
When directions change, the new numbers are printed on the new label. Never carry a number over from a previous fill. Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account.
Hexarelin Dosage
Side effects, in summary
| What is reported | What to do |
|---|---|
| Warmth or flushing after the injection | Usually settles; report it if marked |
| Hunger after a dose | Report it, especially if weight is a concern |
| Transient headache or light-headedness | Report it if it persists |
| Injection-site redness or soreness | Rotate sites |
| Swelling, or glucose problems if you monitor glucose | Class risks of raising growth hormone; message your care team |
| Facial or throat swelling, widespread rash, breathing difficulty | Call 911 first, then tell your physician |
If you think you may have taken too much, call Poison Control at 1-800-222-1222 and message your care team. Do not skip, double or change a dose to compensate. The full list is in hexarelin side effects. Hexarelin is named on the WADA Prohibited List under S2.2.4 and is prohibited at all times in tested sport. Compounded medications are not FDA approved, and hexarelin does not appear in any category of the FDA's 503A list.
Hexarelin Dosage
Where to get hexarelin prescribed
Hexarelin cannot be bought legitimately without a prescription. Sites selling it "for research use only" are not accountable for what is in the vial: identity, purity, sterility and concentration are untested, so the per-dose figures above would not hold. See research peptides vs prescription peptides. The prescription route:
- Complete a free online intake covering your history, medications and what you want help with.
- A physician licensed in your state reviews it, usually within 24 hours.
- If it is appropriate, a PCAB-accredited, FDA-registered US 503A compounding pharmacy prepares it to that prescription. Lot test results are published at /quality/lab-results.
- It ships refrigerated with your directions printed on the vial.
- Your physician stays reachable for questions and dose changes.
Pepti prescribes in most US states, not currently in Oklahoma, and the assessment confirms availability for your state. Step by step: how to get hexarelin prescribed online.
References
What this is based on.
References
- Ghigo E, Arvat E, Gianotti L et al.. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man · J Clin Endocrinol Metab (1994) · PMID 8126144
- Rahim A, O'Neill PA, Shalet SM. Growth hormone status during long-term hexarelin therapy · J Clin Endocrinol Metab (1998) · PMID 9589671
- Rahim A, Shalet SM. Does desensitization to hexarelin occur? · Growth Horm IGF Res (1998) · PMID 10990150
- Ghigo E, Arvat E, Gianotti L et al.. Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging · Eur J Endocrinol (1996) · PMID 8921821
- Klinger B, Silbergeld A, Deghenghi R et al.. Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children · Eur J Endocrinol (1996) · PMID 8766941
- Laron Z, Frenkel J, Deghenghi R et al.. Intranasal administration of the GHRP hexarelin accelerates growth in short children · Clin Endocrinol (Oxf) (1995) · PMID 8548949
- Loche S, Cambiaso P, Carta D et al.. The growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, in short normal and obese children and in hypopituitary subjects · J Clin Endocrinol Metab (1995) · PMID 7852535
- Massoud AF, Hindmarsh PC, Matthews DR, Brook CG. The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity · Clin Endocrinol (Oxf) (1996) · PMID 8762732
- Maccario M, Veldhuis JD, Broglio F et al.. Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans · Eur J Endocrinol (2002) · PMID 11888836
- Arvat E, di Vito L, Maccagno B et al.. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH · Peptides (1997) · PMID 9285939
- Ghigo E, Arvat E, Ramunni J et al.. Adrenocorticotropin- and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome · J Clin Endocrinol Metab (1997) · PMID 9253314
- Arvat E, Ramunni J, Bellone J et al.. The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations · Eur J Endocrinol (1997) · PMID 9437229
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Common questions
Hexarelin Dosage, answered.
At Pepti, 0.25 mL, which is 25 units on a U-100 insulin syringe, injected subcutaneously Monday through Friday nights at bedtime. At 2.5 mg/mL that is 0.625 mg per dose. Your physician sets your directions after reviewing your intake, and your exact dose is printed on the vial.
From a 2.5 mg/mL vial, 0.625 mg (625 micrograms): 25 units is 0.25 mL, multiplied by 2.5 mg/mL.
The number printed on your vial. Pepti's typical directions are 25 units, which is 0.25 mL on a U-100 insulin syringe, where 1 unit is 0.01 mL.
Twenty. A 5 mL vial divided by 0.25 mL per dose is 20 doses, four weeks on a Monday to Friday schedule.
The chart above converts units to millilitres to milligrams for a 2.5 mg/mL vial. It is a conversion, not a list of doses to choose from. Your own label is the one that applies.
At bedtime on the nights your directions say, which at Pepti is Monday through Friday. The bedtime timing lands the pulse on the natural nocturnal growth hormone release.
Because continuous dosing desensitised the growth hormone response in a sixteen-week human study, while short intermittent schedules did not. The two nights off are the practical answer to that data.
Partly, and reversibly, with continuous dosing. In the sixteen-week twice-daily study, the response fell by nearly half and returned to baseline four weeks after stopping. The weekday schedule is designed to stay closer to the intermittent regimens.
At Pepti there is one set of directions on the label, set by your physician after reviewing your intake. There is no separate starter protocol to work out yourself.
No. Take the dose printed on your vial, on the schedule printed on your vial. If you have questions about your dose, message your care team.
No. Pepti vials are multi-dose solutions shipped ready to use, with sterile syringes and alcohol prep pads.
Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account. The free assessment goes to a physician licensed in your state. A consultation does not guarantee a prescription.
Next step
See what a physician recommends for you.
A licensed physician in your state reviews your intake and decides what is appropriate. A consultation does not guarantee a prescription.