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Semax (Injectable)
Cognitive

Semax (Injectable)

Cognitive enhancement

All-in monthly price

$229

No membership fee · this is the full price · free shipping · avg 4-week supply

Medication, provider care, labs & dose adjustments — all in one price.
~28-day supply. Your provider sets your exact dose, so yours may vary — your refill arrives as you finish the last one.
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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Dr. Gene
Physician Reviewed

Reviewed by Dr. Gene, MD · Board-certified Family Medicine

Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.

About

Semax (Injectable)

A neuropeptide that enhances BDNF expression, supporting memory, focus, and cognitive performance.

Benefits
Memory support
Neuroprotection
Mental performance
BDNF boost
Supply per fill
28-day

About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.

Physician review
24 hrs

A licensed US physician reviews your intake and prescribes when appropriate.

FDA-registered pharmacy
503A

Compounded fresh at a US pharmacy and shipped cold-chain to your door.

Shipping, always
Free

Every order ships free — medication, physician care and refills, one all-in price.

Formulation
Injectable vial5 mL · 2 mg/mL
Semax10 mg

Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.

Quality

Every batch independently tested

Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.

USP <71>
Sterility

Confirms the finished preparation is free of viable microorganisms.

USP <85>
Bacterial endotoxins

Screens for endotoxins that can cause fever or inflammatory reactions.

Assay
Potency

Verifies the labeled concentration of the active peptide is what is in the vial.

HPLC
Purity

Checks the active peptide against impurities and degradation products.

Mass spectrometry
Identity

Confirms the peptide in the vial is the correct molecule.

USP <791>
pH

Confirms the solution sits within the range specified for injection.

USP <788>
Particulate matter

Checks the finished vial for visible and sub-visible particles.

USP <1207>
Container closure integrity

Confirms the vial seal holds so sterility is maintained through the beyond-use date.

Recent lots
  • Lot 100526-SEA-2

    Tested 2026-10-07 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    98.7%

  • Lot 092826-SEA-2

    Tested 2026-09-30 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    98.4%

  • Lot 092126-SEA-2

    Tested 2026-09-23 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    98.3%

Compounded by licensed U.S. pharmacies. Prescribed by licensed medical providers. Shipped directly to patients.Documentation available upon request →View lab results by lot →
Your protocol

How Semax is prescribed.

Who it's for
  • Adults who feel foggy, distracted or mentally tired
  • Professionals who want sharper focus without a stimulant
  • People who want a brain peptide as part of a longevity protocol
  • Patients pairing it with Selank for focus plus calm

Your physician decides whether Semax is appropriate for you after reviewing your intake and labs.

Directions & duration

Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.

Cycle. One small injection each day, Monday through Friday. Ongoing monthly treatment; your physician adjusts the dose as your goals evolve.
Directions shown are the pharmacy's standard for this preparation. Your prescription label is the final word.
What's included
  • Licensed physician review of your intake, history, and labs
  • Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
  • Every batch independently tested before release
  • Sterile syringes and alcohol prep pads for injectables
  • Tracked delivery to your door, refills on schedule
  • Message your physician anytime; dose changes without an appointment
Storage & handling
  • Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
  • One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
  • Protect from light. Wipe the stopper with an alcohol pad before every draw.
  • Dispose of syringes in the sharps container per the included instructions.
What to expect

A typical course of Semax.

TimeframeWhat patients commonly report
Week 1Sharper focus and clearer thinking are the earliest reports.
Weeks 2–6Better memory and more mental stamina are what patients report most in this window.
OngoingLong-term treatment. Refills ship every 28 days, and your physician adjusts the dose over time as your goals evolve.
Individual results vary. Compounded medications are not FDA-approved; a licensed physician determines whether treatment is appropriate and monitors your progress.
The full reference

Everything published
about Semax.

How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.

Read the reference
15
References

peer-reviewed, each verified on PubMed

15
Sections

mechanism, evidence, dosing, safety, FAQ

Sep 24
FDA status verified

2026 · checked against fda.gov, not memory

The science

How Semax works, and what the research shows.

How it works

Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) by up to 3x.

It enhances memory consolidation, neuroprotection, and overall cognitive performance.

References

  1. Dolotov OV, Karpenko EA, Inozemtseva LS et al.. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus · Brain Res (2006) · PMID 16996037
  2. Dmitrieva VG, Povarova OV, Skvortsova VI et al.. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia · Cell Mol Neurobiol (2010) · PMID 19633950
  3. Medvedeva EV, Dmitrieva VG, Povarova OV et al.. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis · BMC Genomics (2014) · PMID 24661604
  4. Inozemtseva LS, Yatsenko KA, Glazova NY et al.. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress · Eur J Pharmacol (2024) · PMID 39442746
  5. Gusev EI, Skvortsova VI, Miasoedov NF et al.. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)] · Zh Nevrol Psikhiatr Im S S Korsakova (1997) · PMID 11517472
  6. Miasoedova NF, Skvortsova VI, Nasonov EL et al.. [Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke] · Zh Nevrol Psikhiatr Im S S Korsakova (1999) · PMID 10358912
  7. Gusev EI, Skvortsova VI, Chukanova EI. [Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency] · Zh Nevrol Psikhiatr Im S S Korsakova (2005) · PMID 15792140
  8. Gusev EI, Martynov MY, Kostenko EV et al.. [The efficacy of semax in the treatment of patients at different stages of ischemic stroke] · Zh Nevrol Psikhiatr Im S S Korsakova (2018) · PMID 29798983
  9. Polunin GS, Nurieva SM, Baiandin DL et al.. [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease] · Vestn Oftalmol (2000) · PMID 10741256
  10. Kurysheva NI, Shpak AA, Ioileva EE et al.. [Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone] · Vestn Oftalmol (2001) · PMID 11569188
  11. Lebedeva IS, Panikratova YR, Sokolov OY et al.. Effects of Semax on the Default Mode Network of the Brain · Bull Exp Biol Med (2018) · PMID 30225715
  12. Tsai SJ. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome · Med Hypotheses (2007) · PMID 16996699
  13. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN et al.. Placebos without deception: a randomized controlled trial in irritable bowel syndrome · PLoS One (2010) · PMID 21203519
  14. Panikratova YR, Lebedeva IS, Sokolov OY et al.. Functional Connectomic Approach to Studying Selank and Semax Effects · Dokl Biol Sci (2020) · PMID 32342318
  15. Eremin KO, Kudrin VS, Saransaari P et al.. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents · Neurochem Res (2005) · PMID 16362768

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Important safety information

+

Possible side effects

• Mild nasal irritation (uncommon)

Do not use if you have

• Active cancer or history of cancer (unless approved by oncologist)
• Pregnancy or breastfeeding
• Severe kidney or liver disease
• Known allergy to the peptide or excipients

If you experience severe side effects, call 911 or go to your nearest emergency room.

How supplied

5 mL multi-dose vial, Semax 2 mg/mL (10 mg Semax per vial)

Common questions

Frequently asked
about Semax (Injectable).

A neuropeptide that enhances BDNF expression, supporting memory, focus, and cognitive performance. Semax is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.

32 more questions about Pepti, answered.

One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.

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Pharmacy network accreditation

PCAB-accredited pharmacies on every order.

Every fulfillment runs through a PCAB-accredited pharmacy.

See the lab results
PCAB — Pharmacy Compounding Accreditation Board · Accredited
  • Rigorous third-party quality & safety inspections
  • Cleanliness and sterile processes
  • Proper ingredient sourcing
  • Accurate dosing and formulation
  • Staff training and procedures
  • Accredited by NABP & ACHC