PE-22-28 (Injectable)
TREK-1 mood & neuro peptide
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
PE-22-28 (Injectable)
A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
Checks the active peptide against impurities and degradation products.
Confirms the peptide in the vial is the correct molecule.
Confirms the solution sits within the range specified for injection.
Checks the finished vial for visible and sub-visible particles.
Confirms the vial seal holds so sterility is maintained through the beyond-use date.
- Lot 100526-PE-2
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
101.7%
- Lot 092826-PE-2
Tested 2026-09-30 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
100.9%
- Lot 092126-PE-2
Tested 2026-09-23 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.9%
How PE-22-28 is prescribed.
- Adults with a low, flat mood their physician has evaluated
- People under chronic stress who want support without a conventional antidepressant
- Patients who understand the evidence is from animal studies
- Anyone pairing it with Selank or Semax for mood and focus
Your physician decides whether PE-22-28 is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of PE-22-28.
Everything published
about PE-22-28.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How PE-22-28 works, and what the research shows.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood.
Blocking it is studied for a fast lift in mood and for helping the brain grow new cells.
Rodent studies reported antidepressant-like effects within days and new brain-cell growth.
Djillani and colleagues, 2017There are no published controlled human trials.
References
- Djillani A, Pietri M, Moreno S et al.. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity · Front Pharmacol (2017) · PMID 28955242
- Mazella J, Pétrault O, Lucas G et al.. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design · PLoS Biol (2010) · PMID 20405001
- Heurteaux C, Lucas G, Guy N et al.. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype · Nat Neurosci (2006) · PMID 16906152
- Moha Ou Maati H, Veyssiere J, Labbal F et al.. Spadin as a new antidepressant: absence of TREK-1-related side effects · Neuropharmacology (2012) · PMID 21807005
- Devader C, Khayachi A, Veyssière J et al.. In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin · Br J Pharmacol (2015) · PMID 25598009
- Moha ou Maati H, Bourcier-Lucas C, Veyssiere J et al.. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function · Brain Struct Funct (2016) · PMID 25233810
- Ye D, Li Y, Zhang X et al.. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling · Eur Neuropsychopharmacol (2015) · PMID 26441141
- Hivelin C, Béraud-Dufour S, Devader C et al.. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin · J Diabetes Res (2016) · PMID 28105440
- Devader C, Roulot M, Moréno S et al.. Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients · J Affect Disord (2017) · PMID 27838145
- Roulot M, Minelli A, Bortolomasi M et al.. Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients · Neuropsychiatr Dis Treat (2018) · PMID 30233189
- Qi X, Xu H, Wang L et al.. Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats · ACS Chem Neurosci (2018) · PMID 29952548
- Djillani A, Pietri M, Mazella J et al.. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin · Pharmacol Ther (2019) · PMID 30291907
- Pietri M, Djillani A, Mazella J et al.. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides · Neuropharmacology (2019) · PMID 31325429
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
5 mL multi-dose vial, PE-22-28 2 mg/mL (10 mg PE-22-28 per vial)
Frequently asked
about PE-22-28 (Injectable).
A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved. PE-22-28 is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
PE-22-28 is $219 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
PE-22-28 is commonly prescribed for: Adults with a low, flat mood their physician has evaluated; People under chronic stress who want support without a conventional antidepressant; Patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. PE-22-28 is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. PE-22-28 can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
PE-22-28 is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
33 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $219 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded PE-22-28 with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of PE-22-28 are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and PE-22-28 is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Any dose change is made by your physician from the chart, without an appointment. Message them through your account if you think your dose should change.
Yes. Add PE-22-28 to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded PE-22-28 is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only PE-22-28 sold without a prescription is labeled not for human use and is a different product.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. At Pepti it is prescribed to support mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Individual response varies, and your physician sets expectations at approval.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. Blocking it is studied for a fast lift in mood and for helping the brain grow new cells. Compounded PE-22-28 is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
PE-22-28 is prescribed for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. It is commonly requested by adults with a low, flat mood their physician has evaluated; people under chronic stress who want support without a conventional antidepressant; patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is the reviewing physician's decision.
PE-22-28 is studied for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Rodent studies (Djillani and colleagues, 2017) reported antidepressant-like effects within days and new brain-cell growth. There are no published controlled human trials. References are listed on this page.
PE-22-28 is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules PE-22-28 out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate PE-22-28 is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $219 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg PE-22-28. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. PE-22-28 ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$219 per month covers the compounded PE-22-28, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. PE-22-28 is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
PE-22-28 ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$219 per month at Pepti. That includes the compounded PE-22-28, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies PE-22-28 as a monthly injectable vial with syringes and prep pads included, one vial per month at $219, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes PE-22-28 online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $219 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then PE-22-28 ships from the pharmacy. No clinic visit and no video appointment in most cases. $219 per month, all-in.
Yes, for the real thing. PE-22-28 sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's PE-22-28 is physician-prescribed, pharmacy-compounded, batch-tested, and $219 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $219 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed PE-22-28 online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded PE-22-28 is not FDA-approved.
$219 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and PE-22-28 ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose PE-22-28, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, PE-22-28 ships within 1-3 business days and arrives in 1-3 more; if not, the $219 is refunded.
No. PE-22-28 can be prescribed from the assessment alone at Pepti. Bloodwork is required only for GLP-1s and growth-hormone secretagogues.
Pepti ships PE-22-28 to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about PE-22-28 (Injectable).
- PE-22-28: What It Is, Where to Get It Prescribed, and What It CostsPE-22-28 — 5 mL multi-dose vial, PE-22-28 2 mg/mL (10 mg PE-22-28 per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Peptides for Brain Fog and Focus: What Is Prescribed, and What WorksThe peptides used for brain fog and focus, what each one does in the brain, how they are taken, what they cost, and the medical causes worth ruling out first.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- Do You Need a Doctor to Get Peptides? Yes, and Here Is Exactly WhyPeptides used clinically are prescription medications. Why a prescriber is legally required, what your own doctor will likely say, and what a real review looks like online.
- How to Inject Peptides Safely: Step by Step, Units, Sites and MistakesA practical subcutaneous injection walkthrough: reading your sig, converting millilitres to insulin-syringe units, the ten steps, site rotation, what to do about bubbles and missed doses.
Read more about PE-22-28 (Injectable).
Ready to start with PE-22-28 (Injectable)?
Free assessment. Licensed physicians. Money-back guarantee if not approved.
In your pocket.
Message your medical team, track every order, chart every lab marker. 5.0 on the App Store.
Get the app
PCAB-accredited pharmacies on every order.
Every fulfillment runs through a PCAB-accredited pharmacy.
See the lab results
- Rigorous third-party quality & safety inspections
- Cleanliness and sterile processes
- Proper ingredient sourcing
- Accurate dosing and formulation
- Staff training and procedures
- Accredited by NABP & ACHC