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Hexarelin (Injectable)
Anti-Aging

Hexarelin (Injectable)

GH secretagogue

All-in monthly price

$209

No membership fee · this is the full price · free shipping · avg 4-week supply

Medication, provider care, labs & dose adjustments — all in one price.
~28-day supply. Your provider sets your exact dose, so yours may vary — your refill arrives as you finish the last one.
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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Dr. Gene
Physician Reviewed

Reviewed by Dr. Gene, MD · Board-certified Family Medicine

Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.

About

Hexarelin (Injectable)

Hexarelin prompts the body to release more of its own growth hormone. It is among the stronger peptides that do this, and it is also studied for protecting heart muscle. Used for recovery, sleep and body composition. Compounded; not FDA-approved.

Benefits
Strong growth-hormone release
Studied for heart-muscle support
Recovery and lean-muscle support
Nightly injection, Monday to Friday
Supply per fill
28-day

About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.

Physician review
24 hrs

A licensed US physician reviews your intake and prescribes when appropriate.

FDA-registered pharmacy
503A

Compounded fresh at a US pharmacy and shipped cold-chain to your door.

Shipping, always
Free

Every order ships free — medication, physician care and refills, one all-in price.

Formulation
Injectable vial5 mL · 2.5 mg/mL
Hexarelin12.5 mg

Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.

Quality

Every batch independently tested

Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.

USP <71>
Sterility

Confirms the finished preparation is free of viable microorganisms.

USP <85>
Bacterial endotoxins

Screens for endotoxins that can cause fever or inflammatory reactions.

Assay
Potency

Verifies the labeled concentration of the active peptide is what is in the vial.

HPLC
Purity

Checks the active peptide against impurities and degradation products.

Mass spectrometry
Identity

Confirms the peptide in the vial is the correct molecule.

USP <791>
pH

Confirms the solution sits within the range specified for injection.

USP <788>
Particulate matter

Checks the finished vial for visible and sub-visible particles.

USP <1207>
Container closure integrity

Confirms the vial seal holds so sterility is maintained through the beyond-use date.

Recent lots
  • Lot 100526-HEX-0.4

    Tested 2026-10-07 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.6%

  • Lot 092826-HEX-0.4

    Tested 2026-09-30 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.2%

  • Lot 092126-HEX-0.4

    Tested 2026-09-23 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.2%

Compounded by licensed U.S. pharmacies. Prescribed by licensed medical providers. Shipped directly to patients.Documentation available upon request →View lab results by lot →
Your protocol

How Hexarelin is prescribed.

Who it's for
  • Adults who want a stronger growth-hormone peptide than ipamorelin for recovery and lean muscle
  • People over 35 who feel workouts take longer to bounce back from
  • Patients whose physician wants to rotate secretagogues to keep the response strong
  • Anyone interested in the heart-support research behind it

Your physician decides whether Hexarelin is appropriate for you after reviewing your intake and labs.

Directions & duration

Inject 0.25 mL (25 units) subcutaneously Monday through Friday nights at bedtime.

Cycle. One small injection at bedtime, Monday through Friday. Ongoing monthly treatment; your physician adjusts the dose as your goals evolve.
Directions shown are the pharmacy's standard for this preparation. Your prescription label is the final word.
What's included
  • Licensed physician review of your intake, history, and labs
  • Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
  • Every batch independently tested before release
  • Sterile syringes and alcohol prep pads for injectables
  • Tracked delivery to your door, refills on schedule
  • Message your physician anytime; dose changes without an appointment
Storage & handling
  • Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
  • One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
  • Protect from light. Wipe the stopper with an alcohol pad before every draw.
  • Dispose of syringes in the sharps container per the included instructions.
What to expect

A typical course of Hexarelin.

TimeframeWhat patients commonly report
Weeks 1–2Deeper sleep and more vivid dreams are the most common early reports. Some redness at the injection site is normal.
Weeks 3–8Better recovery from workouts, steadier energy and a leaner feel are the changes patients report most in this window.
OngoingLong-term treatment. Refills ship every 28 days, and your physician adjusts the dose over time as your goals evolve.
Individual results vary. Compounded medications are not FDA-approved; a licensed physician determines whether treatment is appropriate and monitors your progress.
The full reference

Everything published
about Hexarelin.

How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.

Read the reference
39
References

peer-reviewed, each verified on PubMed

15
Sections

mechanism, evidence, dosing, safety, FAQ

Sep 24
FDA status verified

2026 · checked against fda.gov, not memory

The science

How Hexarelin works, and what the research shows.

How it works

Hexarelin mimics the body's hunger hormone signal, which tells the pituitary gland to release a pulse of growth hormone.

It is a larger pulse than gentler peptides like ipamorelin produce.

It also binds a receptor in heart muscle, which is why it is studied for heart protection.

Clinical evidence
  • Human studies in the 1990s (Ghigo, Arvat and colleagues) showed strong growth-hormone release in adults, with the response easing somewhat when used continuously.

  • Heart-muscle effects are documented in animal studies and small human series.

Full references with PubMed links are listed further down the page.

References

  1. Ghigo E, Arvat E, Gianotti L et al.. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man · J Clin Endocrinol Metab (1994) · PMID 8126144
  2. Rahim A, O'Neill PA, Shalet SM. Growth hormone status during long-term hexarelin therapy · J Clin Endocrinol Metab (1998) · PMID 9589671
  3. Rahim A, Shalet SM. Does desensitization to hexarelin occur? · Growth Horm IGF Res (1998) · PMID 10990150
  4. Ghigo E, Arvat E, Gianotti L et al.. Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging · Eur J Endocrinol (1996) · PMID 8921821
  5. Klinger B, Silbergeld A, Deghenghi R et al.. Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children · Eur J Endocrinol (1996) · PMID 8766941
  6. Laron Z, Frenkel J, Deghenghi R et al.. Intranasal administration of the GHRP hexarelin accelerates growth in short children · Clin Endocrinol (Oxf) (1995) · PMID 8548949
  7. Loche S, Cambiaso P, Carta D et al.. The growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, in short normal and obese children and in hypopituitary subjects · J Clin Endocrinol Metab (1995) · PMID 7852535
  8. Massoud AF, Hindmarsh PC, Matthews DR, Brook CG. The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity · Clin Endocrinol (Oxf) (1996) · PMID 8762732
  9. Maccario M, Veldhuis JD, Broglio F et al.. Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans · Eur J Endocrinol (2002) · PMID 11888836
  10. Arvat E, di Vito L, Maccagno B et al.. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH · Peptides (1997) · PMID 9285939
  11. Ghigo E, Arvat E, Ramunni J et al.. Adrenocorticotropin- and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome · J Clin Endocrinol Metab (1997) · PMID 9253314
  12. Arvat E, Ramunni J, Bellone J et al.. The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations · Eur J Endocrinol (1997) · PMID 9437229
  13. Arvat E, Gianotti L, Grottoli S et al.. Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects · J Clin Endocrinol Metab (1994) · PMID 7962341
  14. Arvat E, Maccario M, Di Vito L et al.. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone · J Clin Endocrinol Metab (2001) · PMID 11238504
  15. Gasperi M, Aimaretti G, Scarcello G et al.. Low dose hexarelin and growth hormone (GH)-releasing hormone as a diagnostic tool for the diagnosis of GH deficiency in adults: comparison with insulin-induced hypoglycemia test · J Clin Endocrinol Metab (1999) · PMID 10443652
  16. Korbonits M, Kaltsas G, Perry LA et al.. Hexarelin as a test of pituitary reserve in patients with pituitary disease · Clin Endocrinol (Oxf) (1999) · PMID 10469018
  17. Maheshwari HG, Rahim A, Shalet SM, Baumann G. Selective lack of growth hormone (GH) response to the GH-releasing peptide hexarelin in patients with GH-releasing hormone receptor deficiency · J Clin Endocrinol Metab (1999) · PMID 10084578
  18. De Marinis L, Mancini A, Valle D et al.. Role of food intake in the modulation of hexarelin-induced growth hormone release in normal human subjects · Horm Metab Res (2000) · PMID 10824712
  19. Bisi G, Podio V, Valetto MR et al.. Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans · J Endocrinol Invest (1999) · PMID 10342360
  20. Broglio F, Guarracino F, Benso A et al.. Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery · Eur J Pharmacol (2002) · PMID 12144941
  21. Imazio M, Bobbio M, Broglio F et al.. GH-independent cardiotropic activities of hexarelin in patients with severe left ventricular dysfunction due to dilated and ischemic cardiomyopathy · Eur J Heart Fail (2002) · PMID 11959048
  22. Locatelli V, Rossoni G, Schweiger F et al.. Growth hormone-independent cardioprotective effects of hexarelin in the rat · Endocrinology (1999) · PMID 10465272
  23. Tivesten A, Bollano E, Caidahl K et al.. The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction · Endocrinology (2000) · PMID 10614623
  24. Bodart V, Febbraio M, Demers A et al.. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart · Circ Res (2002) · PMID 11988484
  25. Xu X, Pang J, Yin H et al.. Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat · Am J Physiol Heart Circ Physiol (2007) · PMID 17766487
  26. Xu X, Ding F, Pang J et al.. Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat · Am J Physiol Heart Circ Physiol (2012) · PMID 22842067
  27. McDonald H, Peart J, Kurniawan N et al.. Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction · Physiol Rep (2018) · PMID 29756411
  28. Pang JJ, Xu RK, Xu XB et al.. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro · Am J Physiol Heart Circ Physiol (2004) · PMID 14615277
  29. Filigheddu N, Fubini A, Baldanzi G et al.. Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death · Endocrine (2001) · PMID 11322493
  30. Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin · J Geriatr Cardiol (2014) · PMID 25278975
  31. De Gennaro-Colonna V, Rossoni G, Cocchi D et al.. Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker rats · J Endocrinol (2000) · PMID 10974647
  32. Pang J, Xu Q, Xu X et al.. Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat · Peptides (2010) · PMID 19931584
  33. Mosa R, Huang L, Wu Y et al.. Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice · Endocrinology (2017) · PMID 28977588
  34. Demers A, Rodrigue-Way A, Tremblay A. Hexarelin Signaling to PPARgamma in Metabolic Diseases · PPAR Res (2008) · PMID 18288286
  35. Orkin RD, New DI, Norman D et al.. Rapid desensitisation of the GH secretagogue (ghrelin) receptor to hexarelin in vitro · J Endocrinol Invest (2003) · PMID 14669829
  36. Imbimbo BP, Mant T, Edwards M et al.. Growth hormone-releasing activity of hexarelin in humans. A dose-response study · Eur J Clin Pharmacol (1994) · PMID 7957536
  37. Semenistaya E, Zvereva I, Thomas A et al.. Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin · Drug Test Anal (2015) · PMID 25869809
  38. Camiña JP, Carreira MC, El Messari S, Llorens-Cortes C, Smith RG, Casanueva FF. Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a · Endocrinology (2004) · PMID 14576181
  39. Delhanty PJ, van Kerkwijk A, Huisman M, van de Zande B et al.. Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization · Am J Physiol Endocrinol Metab (2010) · PMID 20587751

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Important safety information

+

Possible side effects

• Mild redness or swelling at injection site
• Temporary fatigue or headache
• Mild nausea (uncommon)

Do not use if you have

• Active cancer or history of cancer (unless approved by oncologist)
• Pregnancy or breastfeeding
• Severe kidney or liver disease
• Known allergy to the peptide or excipients

If you experience severe side effects, call 911 or go to your nearest emergency room.

How supplied

vial — Hexarelin 12.5mg/5mL 2.5mg/mL (5mL)

Common questions

Frequently asked
about Hexarelin (Injectable).

Hexarelin prompts the body to release more of its own growth hormone. It is among the stronger peptides that do this, and it is also studied for protecting heart muscle. Used for recovery, sleep and body composition. Compounded; not FDA-approved. Hexarelin is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.

33 more questions about Pepti, answered.

One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.

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Pharmacy network accreditation

PCAB-accredited pharmacies on every order.

Every fulfillment runs through a PCAB-accredited pharmacy.

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PCAB — Pharmacy Compounding Accreditation Board · Accredited
  • Rigorous third-party quality & safety inspections
  • Cleanliness and sterile processes
  • Proper ingredient sourcing
  • Accurate dosing and formulation
  • Staff training and procedures
  • Accredited by NABP & ACHC