“I noticed I felt less worn out on busy mornings after trying FOXO4-DRI.”

FOXO4-DRI (Injectable)
Senolytic peptide
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
FDA status: Compounded medication, not FDA-approved. No FDA-approved drug contains it. Status of every medication
What patients say about FOXO4-DRI
“I started getting through my morning chores in one go.”
“On Saturdays I had energy left after taking care of the yard.”
“I noticed a difference on active days more than quiet ones.”
FOXO4-DRI (Injectable)
FOXO4-DRI is a research peptide studied for clearing senescent cells, the worn-out cells that stop dividing but linger and drive inflammation as we age. Human evidence is limited, so it is prescribed only where a physician judges it appropriate. Compounded; not FDA-approved.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
How FOXO4-DRI is prescribed.
- Adults pursuing a longevity protocol under physician supervision
- People who feel recovery, energy and skin have slowed with age and want to work on the cellular side of it
- Patients who understand the evidence is from animal studies and are comfortable with that
- Someone who wants a longevity peptide that is not a hormone
Your physician decides whether FOXO4-DRI is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of FOXO4-DRI.
Everything published
about FOXO4-DRI.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How FOXO4-DRI works, and what the research shows.
Old, worn-out cells survive by holding a protein called p53 in check.
FOXO4-DRI breaks that hold inside those cells only, so they self-destruct while healthy cells are left alone.
Clearing them is studied for reducing the low-grade inflammation of aging.
In aged mice, a 2017 study (Baar and colleagues, Cell) reported cleared senescent cells, thicker fur, more activity and improved kidney function.
There are no published controlled human trials.
References
- Baar MP, Brandt RMC, Putavet DA et al.. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging · Cell (2017) · PMID 28340339
- Bourgeois B, Spreitzer E, Platero-Rochart D et al.. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI · Nature Communications (2025) · PMID 40593617
- Zhang C, Xie Y, Chen H et al.. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice · Aging (Albany NY) (2020) · PMID 31959736
- Huang Y, He Y, Makarcyzk MJ et al.. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes · Frontiers in Bioengineering and Biotechnology (2021) · PMID 33996787
- Liu Y, Hou Q, Wang R et al.. FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice · Naunyn-Schmiedeberg's Archives of Pharmacology (2023) · PMID 37074394
- Li Y, Zhang C, Cheng H et al.. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells · Experimental Gerontology (2024) · PMID 39025385
- Hu Z, Li F, Hu C et al.. FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway · Frontiers in Bioengineering and Biotechnology (2026) · PMID 41625068
- Kong YX, Li ZS, Liu YB et al.. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation · Communications Biology (2025) · PMID 39994346
- Born E, Lipskaia L, Breau M et al.. Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression · Circulation (2023) · PMID 36515093
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
vial — FOXO4-DRI 10mg/5mL 2mg/mL (5mL)
Frequently asked
about FOXO4-DRI (Injectable).
FOXO4-DRI is a research peptide studied for clearing senescent cells, the worn-out cells that stop dividing but linger and drive inflammation as we age. Human evidence is limited, so it is prescribed only where a physician judges it appropriate. Compounded; not FDA-approved. FOXO4-DRI is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
FOXO4-DRI is $229 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
FOXO4-DRI is commonly prescribed for: Adults pursuing a longevity protocol under physician supervision; People who feel recovery, energy and skin have slowed with age and want to work on the cellular side of it; Patients who understand the evidence is from animal studies and are comfortable with that; Someone who wants a longevity peptide that is not a hormone. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. FOXO4-DRI is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. FOXO4-DRI can be prescribed from the assessment alone. If your physician wants labs for your care, they'll ask through your account; upload a recent lab report from any lab at no charge, or order Pepti's at-home panel.
FOXO4-DRI is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
33 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $229 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded FOXO4-DRI with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of FOXO4-DRI are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and FOXO4-DRI is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add FOXO4-DRI to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded FOXO4-DRI is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only FOXO4-DRI sold without a prescription is labeled not for human use and is a different product.
Old, worn-out cells survive by holding a protein called p53 in check. At Pepti it is prescribed to support studied for clearing worn-out cells, a longevity research peptide, evidence is from animal studies, daily injection, monday to friday. Individual response varies, and your physician sets expectations at approval.
Old, worn-out cells survive by holding a protein called p53 in check. FOXO4-DRI breaks that hold inside those cells only, so they self-destruct while healthy cells are left alone. Clearing them is studied for reducing the low-grade inflammation of aging. Compounded FOXO4-DRI is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
FOXO4-DRI is prescribed for studied for clearing worn-out cells, a longevity research peptide, evidence is from animal studies, daily injection, monday to friday. It is commonly requested by adults pursuing a longevity protocol under physician supervision; people who feel recovery, energy and skin have slowed with age and want to work on the cellular side of it; patients who understand the evidence is from animal studies and are comfortable with that; Someone who wants a longevity peptide that is not a hormone. Whether it is appropriate for you is the reviewing physician's decision.
FOXO4-DRI is studied for studied for clearing worn-out cells, a longevity research peptide, evidence is from animal studies, daily injection, monday to friday. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
In aged mice, a 2017 study (Baar and colleagues, Cell) reported cleared senescent cells, thicker fur, more activity and improved kidney function. There are no published controlled human trials. References are listed on this page.
FOXO4-DRI is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules FOXO4-DRI out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate FOXO4-DRI is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $229 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg FOXO4-DRI. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. FOXO4-DRI ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 24 other treatments.
$229 per month covers the compounded FOXO4-DRI, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. FOXO4-DRI is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
FOXO4-DRI ships to 49 states and Washington, D.C, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$229 per month at Pepti. That includes the compounded FOXO4-DRI, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies FOXO4-DRI as a monthly injectable vial with syringes and prep pads included, one vial per month at $229, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes FOXO4-DRI online in 49 states and Washington, D.C after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $229 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then FOXO4-DRI ships from the pharmacy. No clinic visit and no video appointment in most cases. $229 per month, all-in.
Yes, for the real thing. FOXO4-DRI sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's FOXO4-DRI is physician-prescribed, pharmacy-compounded, batch-tested, and $229 per month including the physician and shipping.
Pepti does, in 49 states and Washington, D.C, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $229 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed FOXO4-DRI online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded FOXO4-DRI is not FDA-approved.
$229 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and FOXO4-DRI ships free from the pharmacy to your door in 49 states and Washington, D.C.
Start the free assessment at hellopepti.com, choose FOXO4-DRI, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, FOXO4-DRI ships the next business day and arrives overnight; if not, the $229 is refunded.
No. FOXO4-DRI can be prescribed from the assessment alone at Pepti. If your physician wants labs for your care, they'll ask through your account; upload a lab report from any lab, or order a Pepti at-home panel from $129.
Pepti ships FOXO4-DRI to 49 states and Washington, D.C, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. It ships the next business day and arrives overnight.
Questions people ask
about FOXO4-DRI (Injectable).
- FOXO4-DRI: What It Is, Where to Get It Prescribed, and What It CostsFOXO4-DRI — vial — FOXO4-DRI 10mg/5mL 2mg/mL (5mL). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- FOXO4-DRI Dosage: How Pepti Prescribes It, in Units, mL and mgThe FOXO4-DRI dosage Pepti prescribes: 0.25 mL (25 units on a U-100 insulin syringe) under the skin once daily Monday through Friday, 0.5 mg per dose from a 2 mg/mL vial, 20 doses per vial. Includes a units, mL and mg chart, why the mouse studies cannot give a human dose, and what can change your directions.
- FOXO4-DRI Side Effects: What Is Known, What Is Not, and What to Watch ForA practical reference to FOXO4-DRI side effects: why its safety record is a mouse record, what prescribers see with the injection, the theoretical immune question from its D-amino acid and cell-penetrating chemistry, the p53 and cancer caution, the 2023 mouse finding on senolytics and pulmonary hypertension, when to get emergency care, and who should not take it.
- FOXO4-DRI Benefits: What the Senolytic Research Actually ShowsThe benefits claimed for FOXO4-DRI, one at a time: senescent cell clearance, chemotherapy toxicity, fitness and kidney function in aged mice, Leydig cells and testosterone, fibrosis and scar tissue, and blood vessels, each labelled as mouse or cell research, with what is missing and the dosage printed on the vial.
- Can You Take FOXO4-DRI With Tirzepatide or Semaglutide?FOXO4-DRI and tirzepatide or semaglutide act on unrelated targets, and no study has tested them together. What each one does, why FOXO4-DRI is not a weight medication, how to tell their side effects apart, the cancer-history and lung points, and how to add FOXO4-DRI to a GLP-1 plan properly.
- How Long Does FOXO4-DRI Take to Work? What the Mouse Studies Measured, and WhenNo study has measured how long FOXO4-DRI takes to work in people, because no person has been treated in a published study. What the mouse and cell studies measured and over what period, why mouse timelines do not translate, what "working" would even mean for a senolytic, and what to track.
- Do You Need a Prescription for FOXO4-DRI? Is It Legal to Buy Online?FOXO4-DRI needs a prescription for human use in the US. What the law says, where FOXO4-DRI stands with the FDA, what "research use only" vials actually are, and how the prescription route works.
- Best Place to Get FOXO4-DRI Online: A Provider Checklist, and What Pepti OffersWhere to get FOXO4-DRI prescribed online: what a legitimate provider shows you, the claims that should make you leave, and exactly what Pepti's FOXO4-DRI prescription includes and costs.
- How to Get FOXO4-DRI Prescribed Online: Step by StepHow a FOXO4-DRI prescription works through telehealth: the assessment, what the intake asks and why, physician review, compounding, refrigerated shipping, what to expect from a first vial, refills and cost.
- FOXO4-DRI for Women: What Research Has Looked At, and What to Check FirstWhat research has looked at for FOXO4-DRI in women: no study of women specifically, no human treatment trial, and only mouse and human-cell work in either sex. Pregnancy and breastfeeding, the skin and keloid research, menopause, cancer history, and how to get FOXO4-DRI prescribed.
- FOXO4-DRI for Men: What the Testosterone and Leydig Cell Research Actually ShowsWhat research has looked at for FOXO4-DRI in men: two mouse studies on aged Leydig cells, testosterone and sperm quality, one observational look at human testicular tissue, and no human treatment trial. The cancer-history and lung points, what to check first, and how to get FOXO4-DRI prescribed.
- Is FOXO4-DRI Banned in Sports? WADA Status, S0 and Drug TestsFOXO4-DRI is not named on the WADA Prohibited List, but the S0 class for non-approved substances is written to reach experimental peptides like it. What that means for tested athletes, why a prescription does not change it, what a workplace drug test looks for, and where FOXO4-DRI stands with the FDA.
- Peptides for Longevity and Anti-Aging: What Is Actually Prescribed and What the Evidence SaysThe peptides used in longevity protocols, what each one does at the cellular level, which claims outrun the evidence, and what it costs.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- Where to Get Peptides for Anti-Aging Online: How to Choose a ProviderGHK-Cu, NAD+, epithalon, SS-31 and the growth-hormone-axis peptides are prescription-only. Where to get anti-aging peptides online, what a provider should screen for first, the checklist for choosing one, and what Pepti offers.
- How Much Does FOXO4-DRI Cost?FOXO4-DRI cost in 2026: $229 per month all-in at Pepti — compounded medication, physician review, and shipping included. No membership or consult fees.
- Best Peptides for Longevity and Anti-AgingTop longevity peptides ranked: NAD+, GHK-Cu, Epitalon, MOTS-c, SS-31. Doctor-prescribed anti-aging protocols based on telomere maintenance, mitochondrial health, and cellular repair.
Read more about FOXO4-DRI (Injectable).
Best Place to Get FOXO4-DRI Online: A Provider Checklist, and What Pepti Offers
Where to get FOXO4-DRI prescribed online: what a legitimate provider shows you, the claims that should make you leave, and exactly what Pepti's FOXO4-DRI prescription includes and costs.
FOXO4-DRI: What It Is, Where to Get It Prescribed, and What It Costs
FOXO4-DRI — vial — FOXO4-DRI 10mg/5mL 2mg/mL (5mL). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
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