Semaglutide Dosing Chart: Every Dose Step, Units to Draw, and Price

Every price is all-in: medication, physician review, refill management and shipping, with no membership fee. Each step is dispensed as one vial per 28-day fill. Semaglutide is compounded by a PCAB-accredited, FDA-registered US 503A pharmacy and contains no B12. Compounded medications are not FDA approved.

Semaglutide is a once-weekly GLP-1 receptor agonist, a modified copy of a hormone the gut releases after eating. It is started at the lowest strength and stepped up, because the stomach side effects are worst in the days after starting and after each increase. The background on the molecule and its trials is in what is semaglutide, and the class is explained in what is a GLP-1.

At Pepti the sequence works like this:

1. You complete a free online intake covering your history, medications and goals.
2. A physician licensed in your state reviews it, usually within 24 hours, and sets your starting dose.
3. A state-licensed, FDA-registered US pharmacy compounds the vial for that dose, with your directions printed on it.
4. As treatment goes on, your physician reviews how you are doing and moves you up the ladder, holds you at a step, or adjusts your plan.
5. Each 28-day refill is one vial, at whatever dose your physician has set for that fill.

The chart above is the menu of steps. Where you start, how long you stay at a step, and where you settle are set by your physician for you. A higher step is not a better step.

Treatment starts at the lowest strength, 0.25 mg, which is a dose for getting used to the medication rather than a treatment dose. Your physician steps the dose up, typically at roughly four-week intervals as tolerance allows, which lines up with one vial per 28-day fill.

The approved semaglutide label for weight management describes the same pattern: four weeks each at 0.25 mg, 0.5 mg, 1 mg and 1.7 mg once weekly before a maintenance dose. It also builds in room to slow down. If a dose is not tolerated during escalation, the next increase can be delayed for four weeks.

Holding a step is normal

Roughly four weeks is the earliest point an increase is considered, not a schedule that moves you up automatically. Staying on a step for several fills is ordinary, and it is the main adjustment when side effects have not settled. If they have not, tell your care team before your next refill. Your physician reviews how you are doing and sets the dose for that fill.

These are the roles of the steps, not a timeline. Some people stay at a lower step for a long time, some move up steadily, and some do not tolerate semaglutide at all.

Semaglutide slows the rate at which the stomach empties and acts on appetite centers in the brain. Nearly every common side effect is that mechanism at work: nausea, diarrhea, vomiting, constipation, abdominal pain, early fullness and reflux. The approved label states that gastrointestinal reactions increased during dose escalation, and it instructs prescribers to follow the escalation schedule to minimize them.

In the weight-management trials, nausea was reported by 44% of adults on semaglutide against 16% on placebo, and most gastrointestinal effects were mild to moderate and transient. Read the placebo column too: not everything you feel is the drug.

Serious side effects are uncommon but specific: pancreatitis, gallbladder disease, dehydration that can injure the kidneys, and allergic reactions. The full list, the rates against placebo, what helps nausea and constipation and what to report the same day are in semaglutide side effects, with the class overview in GLP-1 side effects.

Pepti prices semaglutide by dose, because a higher step is a vial with more medication in it.

Each price covers one vial per 28-day fill, the physician review, refill management and refrigerated shipping with ice packs, sterile syringes and alcohol prep pads. There is no membership fee. Pepti is cash-pay and does not bill insurance. When your physician moves you to a new step, the new step's price applies from that fill. More detail is on the semaglutide cost page.

The approved semaglutide label for weight management counts back from the next dose rather than forward from the missed one. If the next scheduled dose is more than 2 days away, the missed dose is taken as soon as possible; if it is less than 2 days away, the missed dose is skipped and dosing resumes on the regular day. Never take two doses close together to catch up. The same label says that if 2 or more consecutive doses are missed, escalation restarts at a lower dose to reduce gastrointestinal side effects, so message your care team before restarting after a gap. The detail, including how the windows differ between medications, is in what if I miss a dose of tirzepatide or semaglutide.

Semaglutide ships refrigerated with ice packs and is kept refrigerated. A vial that has frozen should not be used. Beyond-use dating runs from first puncture and is printed on the label. Subcutaneous means into the fat layer; abdomen, thigh and upper arm are the usual sites, rotated, on the same day each week. Semaglutide is supplied as a vial drawn with an insulin syringe, not as a pen. Technique is covered in how to inject peptides safely and storage in how to store peptides.

Semaglutide has the largest human evidence base of any product Pepti prescribes, and the practice of starting low and stepping up comes from the approved label and the trials behind it. Those trials studied the approved manufactured product. A compounded vial contains the same active ingredient, but no trial has been run on a compounded preparation, and compounded medications are not FDA approved.

One risk is specific to compounded vials: dosing error. The FDA has received reports of people drawing the wrong amount from multi-dose vials. That is the reason Pepti prints each dose in both millilitres and syringe units for the exact vial you receive, and the reason this page keeps repeating that units change between steps. If a label does not match what you expected, do not inject; message your care team. Lot test results are published at /quality/lab-results.

Nothing on this page sets anyone's dose. Your physician sets your dose after reviewing your intake, and your directions are printed on the vial.

Semaglutide cannot be bought legitimately without a prescription. Products sold "for research use only" have no pharmacy accountable for identity, purity, sterility or concentration, and without a reliable concentration no unit count means anything. The prescription route:

1. Complete a free online intake covering your history, medications and what you want help with.
2. A physician licensed in your state reviews it, usually within 24 hours.
3. If it is appropriate, a state-licensed, FDA-registered US pharmacy compounds it to that prescription.
4. It ships refrigerated with ice packs, sterile syringes and alcohol prep pads, with your directions printed on the vial.
5. Your care team stays reachable for side effects and dose questions. Refills run every 28 days, one vial per fill.

Bloodwork is not required for any Pepti treatment. If your physician wants labs for your care, they'll ask through your account. The step-by-step page is how to get semaglutide prescribed online.