TB-500 (Injectable)
Deep tissue repair
Choose your strength
Every strength is a 4-week supply. A higher strength means more medication per dose on the same monthly cycle. Your provider confirms the dose at review.
All-in monthly price · 5mg
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
TB-500 (Injectable)
Thymosin Beta-4 promotes cell migration and tissue repair at a systemic level.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
Checks the active peptide against impurities and degradation products.
Confirms the peptide in the vial is the correct molecule.
Confirms the solution sits within the range specified for injection.
Checks the finished vial for visible and sub-visible particles.
Confirms the vial seal holds so sterility is maintained through the beyond-use date.
- Lot 100526-TB-2
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.2%
- Lot 100526-TB-3
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
100.8%
- Lot 100526-TB-6
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
98.5%
How TB-500 is prescribed.
- Adults with soft-tissue injuries or slow-healing strains
- Patients seeking support for flexibility and range of motion during rehab
- Athletes and active adults managing recurring overuse injuries
Your physician decides whether TB-500 is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously Monday through Friday mornings.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of TB-500.
Everything published
about TB-500.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How TB-500 works, and what the research shows.
Thymosin Beta-4 (TB-500) is a 43-amino-acid peptide that promotes cell migration, differentiation, and tissue repair at a systemic level.
It works by binding to actin, supporting wound healing throughout the body — not just at one site.
Thymosin Beta-4's tissue-repair biology is well characterized: it promoted cardiac cell migration and survival after injury in influential animal work and supports corneal and dermal wound healing in preclinical models.
Bock-Marquette et al., Nature 2004Synthetic Tβ4 has reached human trials for wound healing and eye conditions with encouraging safety but limited efficacy data.
TB-500, the widely used fragment of Tβ4, has not itself been through human clinical trials.
References
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues · Trends Mol Med (2005) · PMID 16099219
- Malinda KM, Sidhu GS, Mani H et al.. Thymosin beta4 accelerates wound healing · J Invest Dermatol (1999) · PMID 10469335
- Malinda KM, Goldstein AL, Kleinman HK. Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells · FASEB J (1997) · PMID 9194528
- Philp D, Badamchian M, Scheremeta B et al.. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice · Wound Repair Regen (2003) · PMID 12581423
- Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development · Mech Ageing Dev (2004) · PMID 15037013
- Philp D, Scheremeta B, Sibliss K et al.. Thymosin beta4 promotes matrix metalloproteinase expression during wound repair · J Cell Physiol (2006) · PMID 16607611
- Smart N, Risebro CA, Melville AA et al.. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization · Nature (2007) · PMID 17108969
- Sosne G, Szliter EA, Barrett R et al.. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury · Exp Eye Res (2002) · PMID 11950239
- Sosne G, Hafeez S, Greenberry AL 2nd et al.. Thymosin beta4 promotes human conjunctival epithelial cell migration · Curr Eye Res (2002) · PMID 12324865
- Sosne G, Xu L, Prach L et al.. Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta · Exp Cell Res (2004) · PMID 14729067
- Sosne G, Qiu P, Christopherson PL et al.. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway · Exp Eye Res (2007) · PMID 17254567
- Sosne G, Qiu P, Goldstein AL et al.. Biological activities of thymosin beta4 defined by active sites in short peptide sequences · FASEB J (2010) · PMID 20179146
- Qiu P, Wheater MK, Qiu Y et al.. Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK · FASEB J (2011) · PMID 21343177
- Crockford D. Development of thymosin beta4 for treatment of patients with ischemic heart disease · Ann N Y Acad Sci (2007) · PMID 17947592
- Yang WS, Kang S, Sung J et al.. Thymosin β4: potential to treat epidermolysis bullosa and other severe dermal injuries · Eur J Dermatol (2019) · PMID 31649007
- Gonzalez-Franquesa A, Stocks B, Borg ML et al.. Discovery of thymosin β4 as a human exerkine and growth factor · Am J Physiol Cell Physiol (2021) · PMID 34495765
- Gladka MM, Johansen AKZ, van Kampen SJ et al.. Thymosin β4 and prothymosin α promote cardiac regeneration post-ischaemic injury in mice · Cardiovasc Res (2023) · PMID 36125329
- Biçer O, Adanir O, Güleryüz Y et al.. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study · Jt Dis Relat Surg (2026) · PMID 42542926
- Xiao Y, Chen Y, Wen J et al.. Thymosin β4: a potential molecular target for tumor therapy · Crit Rev Eukaryot Gene Expr (2012) · PMID 22856429
- Huang D, Wang S, Wang A et al.. Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation · Acta Biochim Biophys Sin (Shanghai) (2016) · PMID 27521796
- Rahaman KA, Muresan AR, Min H et al.. Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro · J Chromatogr B Analyt Technol Biomed Life Sci (2024) · PMID 38382158
- Mazzarino M, Colpaert T, Deventer K et al.. Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices · Analyst (2026) · PMID 42328738
- Cha HJ, Jeong MJ, Kleinman HK. Role of thymosin beta4 in tumor metastasis and angiogenesis · J Natl Cancer Inst (2003) · PMID 14625258
- Kobayashi T, Okada F, Fujii N et al.. Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells · Am J Pathol (2002) · PMID 11891186
- Wang WS, Chen PM, Hsiao HL, Ju SY, Su Y. Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells · Oncogene (2003) · PMID 12761500
- Huang HC, Hu CH, Tang MC et al.. Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase · Oncogene (2007) · PMID 17072345
- Ho EN, Kwok WH, Lau MY et al.. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry · J Chromatogr A (2012) · PMID 23084823
- Crockford D, Turjman N, Allan C, Angel J. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications · Ann N Y Acad Sci (2010) · PMID 20536467
- Dunn SP, Heidemann DG, Chow CY et al.. Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4 · Arch Ophthalmol (2010) · PMID 20457990
- Esposito S, Deventer K, Goeman J et al.. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential · Drug Test Anal (2012) · PMID 22962027
- Philp D, Nguyen M, Scheremeta B, St-Surin S, Villa AM, Orgel A, Kleinman HK, Elkin M. Thymosin beta4 increases hair growth by activation of hair follicle stem cells · FASEB J (2004) · PMID 14657002
- Philp D, St-Surin S, Cha HJ, Moon HS, Kleinman HK, Elkin M. Thymosin beta 4 induces hair growth via stem cell migration and differentiation · Ann N Y Acad Sci (2007) · PMID 17947589
- Dai B, Sha RN, Yuan JL, Liu DJ. Multiple potential roles of thymosin β4 in the growth and development of hair follicles · J Cell Mol Med (2021) · PMID 33393222
- Mendias CL, Awan TM. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance · Sports Med (2026) · PMID 41966639
- Tewari K, Liu TP, Im C et al.. Peptide Supplements and Their Therapeutic Applications in Sports Medicine · Am J Sports Med (2026) · PMID 42578445
- Guarnera G, DeRosa A, Camerini R. The effect of thymosin treatment of venous ulcers · Ann N Y Acad Sci (2010) · PMID 20536470
- Krug O, Thomas A, Walpurgis K, Piper T, Sigmund G, Schänzer W, Laussmann T, Thevis M. Identification of black market products and potential doping agents in Germany 2010-2013 · Eur J Clin Pharmacol (2014) · PMID 25168622
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
Important safety information
+
Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
5 mL multi-dose vial, TB-500 1 mg/mL (5 mg TB-500 per vial)
Frequently asked
about TB-500 (Injectable).
Thymosin Beta-4 promotes cell migration and tissue repair at a systemic level. TB-500 is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
TB-500 is $209 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
TB-500 is commonly prescribed for: Adults with soft-tissue injuries or slow-healing strains; Patients seeking support for flexibility and range of motion during rehab; Athletes and active adults managing recurring overuse injuries. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. TB-500 is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. TB-500 can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
TB-500 is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
33 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $209 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded TB-500 with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of TB-500 are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and TB-500 is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add TB-500 to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded TB-500 is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only TB-500 sold without a prescription is labeled not for human use and is a different product.
Thymosin Beta-4 (TB-500) is a 43-amino-acid peptide that promotes cell migration, differentiation, and tissue repair at a systemic level. At Pepti it is prescribed to support tissue repair, flexibility, reduced scarring, wound healing. Individual response varies, and your physician sets expectations at approval.
Thymosin Beta-4 (TB-500) is a 43-amino-acid peptide that promotes cell migration, differentiation, and tissue repair at a systemic level. It works by binding to actin, supporting wound healing throughout the body — not just at one site. Compounded TB-500 is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
TB-500 is prescribed for tissue repair, flexibility, reduced scarring, wound healing. It is commonly requested by adults with soft-tissue injuries or slow-healing strains; patients seeking support for flexibility and range of motion during rehab; Athletes and active adults managing recurring overuse injuries. Whether it is appropriate for you is the reviewing physician's decision.
TB-500 is studied for tissue repair, flexibility, reduced scarring, wound healing. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Thymosin Beta-4's tissue-repair biology is well characterized: it promoted cardiac cell migration and survival after injury in influential animal work (Bock-Marquette et al., Nature 2004) and supports corneal and dermal wound healing in preclinical models. Synthetic Tβ4 has reached human trials for wound healing and eye conditions with encouraging safety but limited efficacy data. TB-500, the widely used fragment of Tβ4, has not itself been through human clinical trials. References are listed on this page.
TB-500 is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules TB-500 out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate TB-500 is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $209 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 1 mg/mL, containing 5 mg TB-500. Injectable vial: 5 mL at 2 mg/mL, containing 10 mg TB-500. Injectable vial: 5 mL at 3 mg/mL, containing 15 mg TB-500. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. TB-500 ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$209 per month covers the compounded TB-500, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. TB-500 is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
TB-500 ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$209 per month at Pepti. That includes the compounded TB-500, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies TB-500 as a monthly injectable vial with syringes and prep pads included, one vial per month at $209, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes TB-500 online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $209 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then TB-500 ships from the pharmacy. No clinic visit and no video appointment in most cases. $209 per month, all-in.
Yes, for the real thing. TB-500 sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's TB-500 is physician-prescribed, pharmacy-compounded, batch-tested, and $209 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $209 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed TB-500 online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded TB-500 is not FDA-approved.
$209 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and TB-500 ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose TB-500, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, TB-500 ships within 1-3 business days and arrives in 1-3 more; if not, the $209 is refunded.
No. TB-500 can be prescribed from the assessment alone at Pepti. Bloodwork is required only for GLP-1s and growth-hormone secretagogues.
Pepti ships TB-500 to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about TB-500 (Injectable).
- TB-500: What It Is, Where to Get It Prescribed, and What It CostsTB-500 — 5 mL multi-dose vial, TB-500 1 mg/mL (5 mg TB-500 per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Is TB-500 Safe? Side Effects, Cancer Cautions and What Is Not KnownThe safety picture for TB-500: what thymosin beta-4 research reports, the side effects patients describe, who should avoid it, and the monitoring a physician applies.
- Where to Buy TB-500 Online: Prescription Route, Costs and Red FlagsTB-500 is sold two ways that look alike online. This explains what TB-500 is, how the prescription route works, what it costs, and how to check any seller in ten minutes.
- BPC-157 vs TB-500: Mechanism, Cost, and Why They Are CombinedA head-to-head comparison of the two repair peptides: what each does mechanistically, what each is chosen for, dosing rhythm, side-effect profile, price, and who suits which.
- Peptides for Healing: What Is Actually Prescribed, How Each One Works, and What It CostsA complete guide to the peptides used for healing and recovery: what each contains, what it does at which stage of repair, how they are dosed, what they cost, and when a peptide is the wrong tool.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
Read more about TB-500 (Injectable).
TB-500: What It Is, Where to Get It Prescribed, and What It Costs
TB-500 — 5 mL multi-dose vial, TB-500 1 mg/mL (5 mg TB-500 per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
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