IGF-1 LR3 (Injectable)
Insulin-like growth factor analog
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
IGF-1 LR3 (Injectable)
IGF-1 LR3 is a modified version of Insulin-like Growth Factor 1 with a longer half-life. It is prescribed only after a physician reviews your intake and labs, and is not appropriate for every patient.
About a 4-week supply supply at the standard prescribed dose — your physician confirms exact dosing.
A licensed US physician reviews your intake and prescribes when appropriate.
Compounded fresh at a US pharmacy and shipped cold-chain to your door.
Every order ships free — medication, physician care and refills, one all-in price.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Confirms the finished preparation is free of viable microorganisms.
Screens for endotoxins that can cause fever or inflammatory reactions.
Verifies the labeled concentration of the active peptide is what is in the vial.
Checks the active peptide against impurities and degradation products.
Confirms the peptide in the vial is the correct molecule.
Confirms the solution sits within the range specified for injection.
Checks the finished vial for visible and sub-visible particles.
Confirms the vial seal holds so sterility is maintained through the beyond-use date.
- Lot 100526-IGF-0.2
Tested 2026-10-07 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.5%
- Lot 092826-IGF-0.2
Tested 2026-09-30 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.3%
- Lot 092126-IGF-0.2
Tested 2026-09-23 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.8%
How IGF-1 LR3 is prescribed.
- Adults whose physician is supporting muscle recovery and growth
- Experienced patients already comfortable with peptide protocols
Your physician decides whether IGF-1 LR3 is appropriate for you after reviewing your intake and labs.
Inject 0.25 mL (25 units) subcutaneously Monday through Friday nights at bedtime.
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
A typical course of IGF-1 LR3.
Everything published
about IGF-1 LR3.
How it is described to work, pathway by pathway. What the research shows and what it does not. Where it stands with the FDA, dated and sourced.
Read the referencepeer-reviewed, each verified on PubMed
mechanism, evidence, dosing, safety, FAQ
2026 · checked against fda.gov, not memory
How IGF-1 LR3 works, and what the research shows.
IGF-1 LR3 is a modified insulin-like growth factor 1 with an arginine substitution and 13-amino-acid extension that sharply reduce binding to IGF-binding proteins — keeping more of the peptide free and active, with a substantially longer effective half-life than native IGF-1.
It signals through the IGF-1 receptor, the body's primary mediator of growth-hormone-driven tissue growth.
Native IGF-1 (mecasermin) is FDA-approved for severe primary IGF-1 deficiency, which anchors the receptor biology in approved human medicine.
The LR3 analog itself, however, has no human clinical trials — its anabolic data comes from laboratory and animal research, making it one of the more investigational peptides physicians prescribe.
References
- Philippou A, Maridaki M, Halapas A et al.. The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology · In Vivo (2007) · PMID 17354613
- Francis GL, Ross M, Ballard FJ et al.. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency · J Mol Endocrinol (1992) · PMID 1378742
- Tomas FM, Knowles SE, Owens PC et al.. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats · Biochem J (1992) · PMID 1371669
- Read LC, Tomas FM, Howarth GS et al.. Insulin-like growth factor-I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats · J Endocrinol (1992) · PMID 1613443
- Conlon MA, Tomas FM, Owens PC et al.. Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig · J Endocrinol (1995) · PMID 7561636
- Guler HP, Zapf J, Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults · N Engl J Med (1987) · PMID 3299085
- Chernausek SD, Backeljauw PF, Frane J et al.. Long-term treatment with recombinant insulin-like growth factor (IGF)-I in children with severe IGF-I deficiency due to growth hormone insensitivity · J Clin Endocrinol Metab (2007) · PMID 17192294
- Renehan AG, Zwahlen M, Minder C et al.. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis · Lancet (2004) · PMID 15110491
- Adams GR, McCue SA. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats · J Appl Physiol (1998) · PMID 9572822
- Musarò A, McCullagh K, Paul A et al.. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle · Nat Genet (2001) · PMID 11175789
- Barton-Davis ER, Shoturma DI, Musaro A et al.. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function · Proc Natl Acad Sci U S A (1998) · PMID 9861016
- Allard JB, Duan C. IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? · Front Endocrinol (Lausanne) (2018) · PMID 29686648
- Kohler M, Thomas A, Walpurgis K et al.. Detection of His-tagged Long-R3-IGF-I in a black market product · Growth Horm IGF Res (2010) · PMID 20675162
- Knuppel A, Fensom GK, Watts EL et al.. Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank · Cancer Res (2020) · PMID 32709735
- Watts EL, Perez-Cornago A, Fensom GK et al.. Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis · Int J Epidemiol (2023) · PMID 35726641
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
5 mL multi-dose vial, IGF-LR3 200 mcg/mL (1000 mcg IGF-LR3 per vial)
Frequently asked
about IGF-1 LR3 (Injectable).
IGF-1 LR3 is a modified version of Insulin-like Growth Factor 1 with a longer half-life. It is prescribed only after a physician reviews your intake and labs, and is not appropriate for every patient. IGF-1 LR3 is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
IGF-1 LR3 is $259 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
IGF-1 LR3 is commonly prescribed for: Adults whose physician is supporting muscle recovery and growth; Experienced patients already comfortable with peptide protocols. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. IGF-1 LR3 is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. IGF-1 LR3 can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
IGF-1 LR3 is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
32 more questions about Pepti, answered.Show fewer
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $259 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded IGF-1 LR3 with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Like any prescription medication, IGF-1 LR3 can have side effects, and the physician screens your history, current medications, and allergies for anything that would make it inappropriate before prescribing. The medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and IGF-1 LR3 is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add IGF-1 LR3 to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded IGF-1 LR3 is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only IGF-1 LR3 sold without a prescription is labeled not for human use and is a different product.
IGF-1 LR3 is a modified insulin-like growth factor 1 with an arginine substitution and 13-amino-acid extension that sharply reduce binding to IGF-binding proteins — keeping more of the peptide free and active, with a substantially longer effective half-life than native IGF-1. At Pepti it is prescribed to support longer-acting igf-1 analog, supports recovery, physician-supervised, bloodwork-driven dosing. Individual response varies, and your physician sets expectations at approval.
IGF-1 LR3 is a modified insulin-like growth factor 1 with an arginine substitution and 13-amino-acid extension that sharply reduce binding to IGF-binding proteins — keeping more of the peptide free and active, with a substantially longer effective half-life than native IGF-1. It signals through the IGF-1 receptor, the body's primary mediator of growth-hormone-driven tissue growth. Compounded IGF-1 LR3 is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
IGF-1 LR3 is prescribed for longer-acting igf-1 analog, supports recovery, physician-supervised, bloodwork-driven dosing. It is commonly requested by adults whose physician is supporting muscle recovery and growth; Experienced patients already comfortable with peptide protocols. Whether it is appropriate for you is the reviewing physician's decision.
IGF-1 LR3 is studied for longer-acting igf-1 analog, supports recovery, physician-supervised, bloodwork-driven dosing. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Native IGF-1 (mecasermin) is FDA-approved for severe primary IGF-1 deficiency, which anchors the receptor biology in approved human medicine. The LR3 analog itself, however, has no human clinical trials — its anabolic data comes from laboratory and animal research, making it one of the more investigational peptides physicians prescribe. References are listed on this page.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate IGF-1 LR3 is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $259 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 0.2 mg/mL, containing 1 mg IGF-1 LR3. Injectable vial: 5 mL at 1 mg/mL, containing 5 mg IGF-1 LR3. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. IGF-1 LR3 ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$259 per month covers the compounded IGF-1 LR3, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. IGF-1 LR3 is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
IGF-1 LR3 ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
$259 per month at Pepti. That includes the compounded IGF-1 LR3, the physician review and ongoing care, free tracked shipping, and messaging, with no membership, consult, or visit fee. The price is the same in every state and every refill is the same price.
Pepti supplies IGF-1 LR3 as a monthly injectable vial with syringes and prep pads included, one vial per month at $259, prescribed by a licensed physician after a free online assessment and shipped free from a state-licensed, FDA-registered pharmacy in insulated packaging.
Yes. Pepti prescribes IGF-1 LR3 online in 50 states after a free assessment reviewed by a physician licensed in your state. It is compounded by an FDA-registered pharmacy and shipped free, $259 per month all-in. Not prescribed means refunded.
Yes. At Pepti the entire process is telehealth: a five-minute online assessment, physician review within 4 hours, then IGF-1 LR3 ships from the pharmacy. No clinic visit and no video appointment in most cases. $259 per month, all-in.
Yes, for the real thing. IGF-1 LR3 sold without a prescription is research-use-only product labeled not for human use, with no physician, no pharmacy, and no verified testing. Pepti's IGF-1 LR3 is physician-prescribed, pharmacy-compounded, batch-tested, and $259 per month including the physician and shipping.
Pepti does, in 50 states, with named board-certified physicians, a state-licensed FDA-registered compounding pharmacy, independent batch testing, and one published all-in price of $259 per month with no membership or consult fee. Refunded if the physician does not prescribe.
It is legal to be prescribed IGF-1 LR3 online by a licensed physician and have it dispensed by a licensed pharmacy, which is how Pepti provides it. Buying it as a research chemical without a prescription is a different product and is not for human use. Compounded IGF-1 LR3 is not FDA-approved.
$259 per month at Pepti, including the medication, the physician, and shipping. Refills are the same price and there is no membership fee.
Yes. Pepti has no clinics: the assessment, physician review, messaging, dose changes, and refills all happen online, and IGF-1 LR3 ships free from the pharmacy to your door in 50 states.
Start the free assessment at hellopepti.com, choose IGF-1 LR3, and answer the health questions. A physician licensed in your state reviews it within 4 hours. If approved, IGF-1 LR3 ships within 1-3 business days and arrives in 1-3 more; if not, the $259 is refunded.
No. IGF-1 LR3 can be prescribed from the assessment alone at Pepti. Bloodwork is required only for GLP-1s and growth-hormone secretagogues.
Pepti ships IGF-1 LR3 to 50 states, free and tracked, refrigerated in insulated packaging, directly from the pharmacy. Delivery is 1-3 business days after the pharmacy compounds it.
Questions people ask
about IGF-1 LR3 (Injectable).
- IGF-1 LR3: What It Is, Where to Get It Prescribed, and What It CostsIGF-1 LR3 — 5 mL multi-dose vial, IGF-LR3 200 mcg/mL (1000 mcg IGF-LR3 per vial). Specification, mechanism, dosing, formats, state availability and how to get it prescribed.
- Peptides for Muscle Growth and Recovery: What Is Actually UsedThe peptides prescribed around training: growth-hormone-axis secretagogues, IGF-1 LR3 and repair peptides, what each does, what they cost, and what they cannot do.
- How Much Do Peptides Cost? Real Monthly Prices and What Drives ThemWhat prescription peptides actually cost per month, why single molecules price differently from four-peptide blends, which costs providers hide behind a low headline, and how to compare.
- Do You Need a Doctor to Get Peptides? Yes, and Here Is Exactly WhyPeptides used clinically are prescription medications. Why a prescriber is legally required, what your own doctor will likely say, and what a real review looks like online.
- How to Inject Peptides Safely: Step by Step, Units, Sites and MistakesA practical subcutaneous injection walkthrough: reading your sig, converting millilitres to insulin-syringe units, the ten steps, site rotation, what to do about bubbles and missed doses.
Read more about IGF-1 LR3 (Injectable).
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