“After trying PE-22-28, I noticed I was less scattered when I sat down to work.”
PE-22-28 (Injectable) in Kentucky
Doctor-prescribed PE-22-28 (Injectable) for Kentucky residents. Reviewed by licensed Kentucky physicians, compounded at FDA-registered pharmacies, and shipped to your door.
All-in monthly price
No membership fee · this is the full price · free shipping · avg 4-week supply
Add in-depth bloodwork
Optional — add a physician-reviewed at-home blood panel to your plan.
Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Reviewed by Dr. Gene, MD · Board-certified Family Medicine
Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.
FDA status: Compounded medication, not FDA-approved. No FDA-approved drug contains it. Status of every medication
What patients say about PE-22-28
“I got through the first item on my list before jumping to the next one.”
“I could follow a long podcast and remember where I left off.”
“It felt subtle, but I lost my train of thought less often.”
How it works in Kentucky
- 1Complete a free online intake (~5 minutes).
- 2A licensed Kentucky physician reviews your case within 24 hours.
- 3Your prescription ships from our FDA-registered compounding pharmacy.
- 4Free shipping arrives 2–4 business days later. Refills ship automatically when your supply runs out — cancel anytime.
What PE-22-28 (Injectable) does
A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved.
Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.
Quality
Every batch independently tested
Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.
Sterility
Rapid sterilityConfirms the finished preparation is free of viable microorganisms.
Bacterial endotoxins
USP <85>Screens for endotoxins that can cause fever or inflammatory reactions.
Potency
AssayVerifies the labeled concentration of the active peptide is what is in the vial.
Recent lots
- Lot 110226-PE-2
Tested 2026-11-04 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.3%
- Lot 102626-PE-2
Tested 2026-10-28 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.4%
- Lot 101926-PE-2
Tested 2026-10-21 · Biolink Life Sciences Carolinas
Sterility
Sterile
Endotoxin
<2 EU/mL
Potency
99.3%
Telemedicine in Kentucky.
Kentucky permits telehealth prescribing under Kentucky Board of Medical Licensure telehealth rules. A Kentucky-licensed physician can establish the patient relationship through online intake review for non-controlled medications. Pepti is available in 49 states and Washington, D.C.
Kentucky cities Pepti serves
+ 4 more cities
, Jeffersontown, Frankfort, Henderson, PaducahYour protocol
How PE-22-28 is prescribed in Kentucky.
Who it's for
- Adults with a low, flat mood their physician has evaluated
- People under chronic stress who want support without a conventional antidepressant
- Patients who understand the evidence is from animal studies
- Anyone pairing it with Selank or Semax for mood and focus
Your physician decides whether PE-22-28 is appropriate for you after reviewing your intake and labs.
Directions & duration
Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.
What's included
- Licensed physician review of your intake, history, and labs
- Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
- Every batch independently tested before release
- Sterile syringes and alcohol prep pads for injectables
- Tracked delivery to your door, refills on schedule
- Message your physician anytime; dose changes without an appointment
Storage & handling
- Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
- One vial is your monthly supply. A fresh vial ships to your Kentucky address every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
- Protect from light. Wipe the stopper with an alcohol pad before every draw.
- Dispose of syringes in the sharps container per the included instructions.
What to expect
A typical course of PE-22-28 in Kentucky.
The science
How PE-22-28 works, and what the research shows.
How it works
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood.
Blocking it is studied for a fast lift in mood and for helping the brain grow new cells.
Clinical evidence
Rodent studies reported antidepressant-like effects within days and new brain-cell growth.
Djillani and colleagues, 2017There are no published controlled human trials.
References
- Djillani A, Pietri M, Moreno S et al.. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity · Front Pharmacol (2017) · PMID 28955242
- Mazella J, Pétrault O, Lucas G et al.. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design · PLoS Biol (2010) · PMID 20405001
- Heurteaux C, Lucas G, Guy N et al.. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype · Nat Neurosci (2006) · PMID 16906152
- Moha Ou Maati H, Veyssiere J, Labbal F et al.. Spadin as a new antidepressant: absence of TREK-1-related side effects · Neuropharmacology (2012) · PMID 21807005
- Devader C, Khayachi A, Veyssière J et al.. In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin · Br J Pharmacol (2015) · PMID 25598009
- Moha ou Maati H, Bourcier-Lucas C, Veyssiere J et al.. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function · Brain Struct Funct (2016) · PMID 25233810
- Ye D, Li Y, Zhang X et al.. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling · Eur Neuropsychopharmacol (2015) · PMID 26441141
- Hivelin C, Béraud-Dufour S, Devader C et al.. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin · J Diabetes Res (2016) · PMID 28105440
- Devader C, Roulot M, Moréno S et al.. Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients · J Affect Disord (2017) · PMID 27838145
- Roulot M, Minelli A, Bortolomasi M et al.. Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients · Neuropsychiatr Dis Treat (2018) · PMID 30233189
- Qi X, Xu H, Wang L et al.. Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats · ACS Chem Neurosci (2018) · PMID 29952548
- Djillani A, Pietri M, Mazella J et al.. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin · Pharmacol Ther (2019) · PMID 30291907
- Pietri M, Djillani A, Mazella J et al.. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides · Neuropharmacology (2019) · PMID 31325429
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
PCAB-accredited pharmacies on every order.
Every fulfillment runs through a PCAB-accredited pharmacy.
See the lab results
- Rigorous third-party quality & safety inspections
- Cleanliness and sterile processes
- Proper ingredient sourcing
- Accurate dosing and formulation
- Staff training and procedures
- Accredited by NABP & ACHC
Frequently asked
about PE-22-28 (Injectable) in Kentucky.
Yes. PE-22-28 (Injectable) is legal when prescribed by a physician licensed in Kentucky and dispensed by an FDA-registered compounding pharmacy. Kentucky permits telehealth prescribing under Kentucky Board of Medical Licensure telehealth rules. A Kentucky-licensed physician can establish the patient relationship through online intake review for non-controlled medications.
Orders ship from our FDA-registered compounding pharmacy the next business day after physician approval and arrive in Kentucky overnight. Pepti serves patients across Kentucky including Louisville, Lexington, Bowling Green, and Owensboro.
No. Pepti operates as a fully telehealth platform in Kentucky. Kentucky permits telehealth prescribing under Kentucky Board of Medical Licensure telehealth rules. A Kentucky-licensed physician can establish the patient relationship through online intake review for non-controlled medications.
PE-22-28 (Injectable) starts at $219 at Pepti. Pepti is subscription-based — your refill ships when your supply runs out, and you can cancel anytime. Pricing is the same nationwide — no Kentucky-specific markup. Shipping is free.
Yes — Pepti is available in 49 states and Washington, D.C. Wherever you are in the country, a physician licensed in your state reviews your intake and your medication ships from an FDA-registered compounding pharmacy.
You don't need an in-person peptide clinic — Pepti provides doctor-prescribed PE-22-28 (Injectable) entirely online anywhere in Kentucky. A physician licensed in Kentucky reviews your intake, and your medication ships from an FDA-registered compounding pharmacy to your door. Unlike "research use only" peptide sites, every Pepti order requires a valid patient-specific prescription and a licensed dispensing pharmacy.
No. "Research use only" PE-22-28 (Injectable) is sold with no prescription, no physician, and no dispensing pharmacy, and is not legally sold for human use — independent testing of research-grade peptides has repeatedly found underdosing, mislabeling, and contamination. Prescription PE-22-28 (Injectable) is compounded for you at an FDA-registered US pharmacy after a licensed physician's review. When comparing PE-22-28 (Injectable) options in Kentucky, only consider providers that can name their prescribing physicians and their dispensing pharmacy.
33 more questions about Pepti, answered.Show fewer
Pepti serves all of Kentucky. A physician licensed in Kentucky reviews every order within 4 hours, the prescription is compounded by a state-licensed, FDA-registered pharmacy, and it ships free and tracked to any Kentucky street address. The price is the same as every other state.
Yes. The whole process is online in Kentucky: a free assessment, physician review, messaging, dose changes, and refills through your Pepti account or the Hello Pepti app. No clinic visit is required.
Pepti ships PE-22-28 to Kentucky directly from the pharmacy: free, tracked, unbranded, in insulated packaging with ice packs for refrigerated medication. The pharmacy ships the next business day and it arrives overnight. PO Boxes are not accepted.
Every treatment on Pepti's catalog ships to Kentucky. Eligibility is confirmed during the assessment from your Kentucky shipping address, and if anything ever cannot ship to your address it is refunded.
The same as everywhere Pepti serves: one all-in monthly price per treatment that includes the medication, the physician, and shipping, with no Kentucky-specific markup and no membership or consult fee. Every price is on the product page.
Yes. Pepti's physicians hold licenses in Kentucky, and only a physician licensed where you live reviews and prescribes your order. Their names and credentials are on the providers page.
Yes. Pepti's partner pharmacies are state-licensed, FDA-registered 503A compounding pharmacies licensed to dispense into Kentucky, and every batch is independently tested before it ships.
A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved. PE-22-28 is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
PE-22-28 is commonly prescribed for: Adults with a low, flat mood their physician has evaluated; People under chronic stress who want support without a conventional antidepressant; Patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. PE-22-28 is prescription-only. The free online assessment takes about five minutes, a physician licensed in Kentucky reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. PE-22-28 can be prescribed from the assessment alone. If your physician wants labs for your care, they'll ask through your account; upload a recent lab report from any lab at no charge, or order Pepti's at-home panel.
PE-22-28 is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $219 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded PE-22-28 with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of PE-22-28 are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and PE-22-28 is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add PE-22-28 to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded PE-22-28 is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in Kentucky. Research-use-only PE-22-28 sold without a prescription is labeled not for human use and is a different product.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. At Pepti it is prescribed to support mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Individual response varies, and your physician sets expectations at approval.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. Blocking it is studied for a fast lift in mood and for helping the brain grow new cells. Compounded PE-22-28 is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
PE-22-28 is prescribed for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. It is commonly requested by adults with a low, flat mood their physician has evaluated; people under chronic stress who want support without a conventional antidepressant; patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is the reviewing physician's decision.
PE-22-28 is studied for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Rodent studies (Djillani and colleagues, 2017) reported antidepressant-like effects within days and new brain-cell growth. There are no published controlled human trials. References are listed on this page.
PE-22-28 is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules PE-22-28 out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in Kentucky reviews it within 4 hours, and if appropriate PE-22-28 is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $219 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg PE-22-28. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. PE-22-28 ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 24 other treatments.
$219 per month covers the compounded PE-22-28, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. PE-22-28 is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
PE-22-28 ships to 49 states and Washington, D.C, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
PE-22-28 (Injectable) in every state
Pepti is available in 49 states and Washington, D.C.
Pepti operates in Kentucky through licensed physician partnerships. Compounded medications are produced at FDA-registered 503A pharmacies. Treatment decisions are made by your prescribing physician.
