— Cognitive · Pricing Guide · 2026
How Much Does PE-22-28 Cost?
PE-22-28 is a peptide fragment of spadin studied as a TREK-1 potassium-channel modulator, explored in research for mood support and neuroprotection. Human evidence is limited; it is prescribed only where a physician judges it appropriate.
— Medication
$219 all-in
Compounded vial from an FDA-registered US pharmacy, one monthly fill
— Physician
Included
Review and ongoing care — no consult fee, no visit fee
— Shipping
Included
Sterile syringes and alcohol prep pads in the box
— Messaging
Unlimited
Message your care team any time — no membership fee
— The price
What you’re paying for.
At Pepti, PE-22-28 is $219 per monthly fill, all-in: the compounded medication from an FDA-registered US pharmacy, physician review and ongoing care, shipping, and unlimited messaging. There is no membership fee, no consult fee, and no visit fee on top. It ships as a multi-dose vial with sterile syringes and alcohol prep pads included.
— Insurance
Paying for PE-22-28.
Compounded PE-22-28 is a cash-pay prescription and is not covered by insurance or Medicare. HSA and FSA funds can usually be applied.
— Common questions
PE-22-28 pricing,
answered.
PE-22-28 costs $219 per month at Pepti. That price is all-in — it includes the compounded medication, the licensed physician who reviews your assessment and manages your care, shipping to your door, and unlimited messaging with your care team. Refills are the same price each month; there is no separate membership, consult, or visit fee.
The compounded PE-22-28 from an FDA-registered 503A pharmacy, the vial with sterile syringes and alcohol prep pads, cold-chain shipping, the physician review of your assessment, ongoing physician care and dose adjustments, and unlimited messaging. If the physician does not approve you, the medication charge is refunded.
Yes. PE-22-28 is prescription-only. At Pepti you complete a free online assessment, a licensed US physician reviews it, and if it is appropriate for you the prescription is sent to a partner pharmacy that compounds it and ships it to you. Compounded PE-22-28 is not FDA-approved; it is prepared to a physician's prescription by a state-licensed, FDA-registered pharmacy.
No. Compounded PE-22-28 is a cash-pay prescription and is not covered by insurance or Medicare. Most patients can use HSA or FSA funds, since it is a physician-prescribed medication. Pepti does not bill insurance, which is part of why there are no consult or visit fees.
Research-use-only peptides are sold without a prescription, without a physician, and without a pharmacy. They are labeled "not for human use" for a reason: no one is verifying the identity, purity, sterility, or dose of what is in the vial. Pepti's $219 covers a licensed physician, a state-licensed FDA-registered compounding pharmacy, and independent batch testing — potency, sterility and bacterial endotoxin — at a third-party laboratory. You are paying for the medication to be what the label says it is.
No — every medication is its own catalog price however many are in the plan. Adding a second medication to the same plan means one assessment, one physician review and one shipment — each medication keeps its own catalog price. If you want several peptides for less, a pharmacy-compounded blend puts two to four in one vial at one price.
Once per fill. One vial is your monthly supply, and a fresh one ships about every 28 days depending on the dose your physician prescribes, billed at the same $219 each time. It renews until you cancel, and you can cancel anytime from your account. There is no contract and no cancellation fee.
Most peptide clinics price PE-22-28 as a medication fee plus an initial consult, a membership or program fee, and follow-up visit fees, and many require in-person visits. Pepti charges one monthly price of $219 that already includes the physician and shipping, with no consult, membership, or visit fees. Some clinics also dispense research-use-only peptides; Pepti dispenses only physician-prescribed, pharmacy-compounded medication.
— More questions26 more questions about Pepti, answered.
A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved. PE-22-28 is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
PE-22-28 is $219 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
PE-22-28 is commonly prescribed for: Adults with a low, flat mood their physician has evaluated; People under chronic stress who want support without a conventional antidepressant; Patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. PE-22-28 is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. PE-22-28 can be prescribed from the assessment alone. If your physician wants labs for your care, they'll ask through your account; upload a recent lab report from any lab at no charge, or order Pepti's at-home panel.
PE-22-28 is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
The compounded PE-22-28 with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of PE-22-28 are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and PE-22-28 is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Yes. Request it from your account or the app; your physician approves or declines. If approved you pay for the additional medication at the pharmacy's cost and the new dose applies to your next shipment.
Yes. Add PE-22-28 to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded PE-22-28 is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only PE-22-28 sold without a prescription is labeled not for human use and is a different product.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. At Pepti it is prescribed to support mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Individual response varies, and your physician sets expectations at approval.
PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood. Blocking it is studied for a fast lift in mood and for helping the brain grow new cells. Compounded PE-22-28 is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
PE-22-28 is prescribed for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. It is commonly requested by adults with a low, flat mood their physician has evaluated; people under chronic stress who want support without a conventional antidepressant; patients who understand the evidence is from animal studies; Anyone pairing it with Selank or Semax for mood and focus. Whether it is appropriate for you is the reviewing physician's decision.
PE-22-28 is studied for mood & stress support, neuroprotection, trek-1 channel activator, rapid-acting research peptide. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
Rodent studies (Djillani and colleagues, 2017) reported antidepressant-like effects within days and new brain-cell growth. There are no published controlled human trials. References are listed on this page.
PE-22-28 is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules PE-22-28 out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate PE-22-28 is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $219 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg PE-22-28. One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. PE-22-28 ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 24 other treatments.
$219 per month covers the compounded PE-22-28, the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. PE-22-28 is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
PE-22-28 ships to 49 states and Washington, D.C, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
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