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All of PE-22-28 (Injectable)
Delaware

PE-22-28 (Injectable) in Delaware

Doctor-prescribed PE-22-28 (Injectable) for Delaware residents. Reviewed by licensed Delaware physicians, compounded at FDA-registered pharmacies, and shipped to your door.

All-in monthly price

$219

No membership fee · this is the full price · free shipping · avg 4-week supply

Medication, provider care, labs & dose adjustments — all in one price.
~28-day supply. Your provider sets your exact dose, so yours may vary — your refill arrives as you finish the last one.
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Add in-depth bloodwork

Optional — add a physician-reviewed at-home blood panel to your plan.

At-home kit (1 device)+$149

Your sex-hormone baseline plus the safety markers that matter on therapy — blood counts, liver and kidney function — from one painless upper-arm device. Matched to your sex (PSA for men; progesterone & FSH for women). No needle, no clinic, physician-reviewed.

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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

Dr. Gene
Physician Reviewed

Reviewed by Dr. Gene, MD · Board-certified Family Medicine

Every Pepti prescription is reviewed by a licensed U.S. physician before it's dispensed — and only provided if clinically appropriate.

FDA status: Compounded medication, not FDA-approved. No FDA-approved drug contains it. Status of every medication

Reviews

What patients say about PE-22-28

4.8
Based on 4 reviews

“After trying PE-22-28, I noticed I was less scattered when I sat down to work.”

Brenda L.Verified buyer

“I got through the first item on my list before jumping to the next one.”

Fiona M.Verified buyer

“I could follow a long podcast and remember where I left off.”

Trevor E.Verified buyer

“It felt subtle, but I lost my train of thought less often.”

Tyler F.Verified buyer
The process

How it works in Delaware

  1. 1Complete a free online intake (~5 minutes).
  2. 2A licensed Delaware physician reviews your case within 24 hours.
  3. 3Your prescription ships from our FDA-registered compounding pharmacy.
  4. 4Free shipping arrives 2–4 business days later. Refills ship automatically when your supply runs out — cancel anytime.
The treatment

What PE-22-28 (Injectable) does

A peptide fragment studied as a TREK-1 potassium channel activator, explored for mood support and neuroprotection. Compounded; not FDA-approved.

✓Mood & stress support
✓Neuroprotection
✓TREK-1 channel activator
✓Rapid-acting research peptide
Formulation
Injectable vial5 mL · 2 mg/mL
PE-22-2810 mg

Amounts shown are per unit. Compounded fresh at a US FDA-registered pharmacy.

Quality

Every batch independently tested

Every medication batch dispensed through Pepti is independently tested by a qualified third-party laboratory for applicable quality and safety standards before the pharmacy releases it. Batches are tested to the same standard used by 503B outsourcing facilities.

Sterility

Rapid sterility

Confirms the finished preparation is free of viable microorganisms.

Bacterial endotoxins

USP <85>

Screens for endotoxins that can cause fever or inflammatory reactions.

Potency

Assay

Verifies the labeled concentration of the active peptide is what is in the vial.

Recent lots

  • Lot 110226-PE-2

    Tested 2026-11-04 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.3%

  • Lot 102626-PE-2

    Tested 2026-10-28 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.4%

  • Lot 101926-PE-2

    Tested 2026-10-21 · Biolink Life Sciences Carolinas

    Sterility

    Sterile

    Endotoxin

    <2 EU/mL

    Potency

    99.3%

Compounded by licensed U.S. pharmacies. Prescribed by licensed medical providers. Shipped directly to patients in Delaware.Documentation available upon request →View lab results by lot →
Delaware

Telemedicine in Delaware.

Delaware permits telemedicine prescribing under the Delaware Telehealth Access Act and Board of Medical Licensure rules. A Delaware-licensed physician can establish the patient relationship through online intake review. Pepti is available in 49 states and Washington, D.C.

Delaware cities Pepti serves

Pepti delivers PE-22-28 (Injectable) to patients across Delaware, including Wilmington, Dover, Newark, Middletown, Smyrna. All shipments use the same FDA-registered compounding pharmacy regardless of city.

Your protocol

How PE-22-28 is prescribed in Delaware.

Who it's for

  • Adults with a low, flat mood their physician has evaluated
  • People under chronic stress who want support without a conventional antidepressant
  • Patients who understand the evidence is from animal studies
  • Anyone pairing it with Selank or Semax for mood and focus

Your physician decides whether PE-22-28 is appropriate for you after reviewing your intake and labs.

Directions & duration

Inject 0.25 mL (25 units) subcutaneously once daily Monday through Friday.

Cycle. One small injection each day, Monday through Friday. Ongoing monthly treatment; your physician adjusts the dose as your goals evolve.
Ready for more? When you're ready for more, ask your physician to double your dose. If approved, the extra vial is billed at cost and applied to your next fill.
Directions shown are the pharmacy's standard for this preparation. Your prescription label is the final word.

What's included

  • Licensed physician review of your intake, history, and labs
  • Medication compounded to your prescription by a PCAB-accredited, FDA-registered pharmacy
  • Every batch independently tested before release
  • Sterile syringes and alcohol prep pads for injectables
  • Tracked delivery to your door, refills on schedule
  • Message your physician anytime; dose changes without an appointment

Storage & handling

  • Store refrigerated (36–46°F / 2–8°C) at all times, including before first use.
  • One vial is your monthly supply. A fresh vial ships to your Delaware address every 28 days on your refill schedule, so you're always well inside the beyond-use date on your label.
  • Protect from light. Wipe the stopper with an alcohol pad before every draw.
  • Dispose of syringes in the sharps container per the included instructions.

What to expect

A typical course of PE-22-28 in Delaware.

TimeframeWhat patients commonly report
Weeks 1–2A lift in mood and motivation is the earliest report; response varies.
Weeks 3–8A steadier mood and better stress tolerance are what patients report most in this window.
OngoingLong-term treatment. Refills ship every 28 days, and your physician adjusts the dose over time as your goals evolve.
Individual results vary. Compounded medications are not FDA-approved; a licensed physician determines whether treatment is appropriate and monitors your progress.

The science

How PE-22-28 works, and what the research shows.

How it works

PE-22-28 is a small piece of a natural brain protein that blocks a channel in nerve cells tied to mood.

Blocking it is studied for a fast lift in mood and for helping the brain grow new cells.

Clinical evidence

  • Rodent studies reported antidepressant-like effects within days and new brain-cell growth.

    Djillani and colleagues, 2017
  • There are no published controlled human trials.

Full references with PubMed links are listed further down the page.

References

  1. Djillani A, Pietri M, Moreno S et al.. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity · Front Pharmacol (2017) · PMID 28955242
  2. Mazella J, Pétrault O, Lucas G et al.. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design · PLoS Biol (2010) · PMID 20405001
  3. Heurteaux C, Lucas G, Guy N et al.. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype · Nat Neurosci (2006) · PMID 16906152
  4. Moha Ou Maati H, Veyssiere J, Labbal F et al.. Spadin as a new antidepressant: absence of TREK-1-related side effects · Neuropharmacology (2012) · PMID 21807005
  5. Devader C, Khayachi A, Veyssière J et al.. In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin · Br J Pharmacol (2015) · PMID 25598009
  6. Moha ou Maati H, Bourcier-Lucas C, Veyssiere J et al.. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function · Brain Struct Funct (2016) · PMID 25233810
  7. Ye D, Li Y, Zhang X et al.. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling · Eur Neuropsychopharmacol (2015) · PMID 26441141
  8. Hivelin C, Béraud-Dufour S, Devader C et al.. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin · J Diabetes Res (2016) · PMID 28105440
  9. Devader C, Roulot M, Moréno S et al.. Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients · J Affect Disord (2017) · PMID 27838145
  10. Roulot M, Minelli A, Bortolomasi M et al.. Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients · Neuropsychiatr Dis Treat (2018) · PMID 30233189
  11. Qi X, Xu H, Wang L et al.. Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats · ACS Chem Neurosci (2018) · PMID 29952548
  12. Djillani A, Pietri M, Mazella J et al.. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin · Pharmacol Ther (2019) · PMID 30291907
  13. Pietri M, Djillani A, Mazella J et al.. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides · Neuropharmacology (2019) · PMID 31325429

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Pharmacy network accreditation

PCAB-accredited pharmacies on every order.

Every fulfillment runs through a PCAB-accredited pharmacy.

See the lab results
PCAB — Pharmacy Compounding Accreditation Board · Accredited
  • Rigorous third-party quality & safety inspections
  • Cleanliness and sterile processes
  • Proper ingredient sourcing
  • Accurate dosing and formulation
  • Staff training and procedures
  • Accredited by NABP & ACHC
Common questions

Frequently asked
about PE-22-28 (Injectable) in Delaware.

Yes. PE-22-28 (Injectable) is legal when prescribed by a physician licensed in Delaware and dispensed by an FDA-registered compounding pharmacy. Delaware permits telemedicine prescribing under the Delaware Telehealth Access Act and Board of Medical Licensure rules. A Delaware-licensed physician can establish the patient relationship through online intake review.

33 more questions about Pepti, answered.

Pepti serves all of Delaware. A physician licensed in Delaware reviews every order within 4 hours, the prescription is compounded by a state-licensed, FDA-registered pharmacy, and it ships free and tracked to any Delaware street address. The price is the same as every other state.

Pepti operates in Delaware through licensed physician partnerships. Compounded medications are produced at FDA-registered 503A pharmacies. Treatment decisions are made by your prescribing physician.