— Supplements · Pricing Guide · 2026
How Much Does Methylcobalamin (B12) Cost?
Methylcobalamin is the active, methylated form of vitamin B12, the form the body uses directly in nerve and red-blood-cell function. The injectable form bypasses oral absorption and is prescribed weekly for energy, cognitive, and nerve-health support.
— Medication
$229 all-in
Compounded vial from an FDA-registered US pharmacy, one monthly fill
— Physician
Included
Review and ongoing care — no consult fee, no visit fee
— Shipping
Included
Sterile syringes and alcohol prep pads in the box
— Messaging
Unlimited
Message your care team any time — no membership fee
— The price
What you’re paying for.
At Pepti, Methylcobalamin (B12) is $229 per monthly fill, all-in: the compounded medication from an FDA-registered US pharmacy, physician review and ongoing care, shipping, and unlimited messaging. There is no membership fee, no consult fee, and no visit fee on top. It ships as a multi-dose vial with sterile syringes and alcohol prep pads included. Vitamin B12 is a lower-cost active than a peptide, which is why it sits at the bottom of the injectable price range.
— Insurance
Paying for Methylcobalamin (B12).
Compounded Methylcobalamin (B12) is a cash-pay prescription and is not covered by insurance or Medicare. HSA and FSA funds can usually be applied.
— Common questions
Methylcobalamin (B12) pricing,
answered.
Methylcobalamin (B12) costs $229 per month at Pepti. That price is all-in — it includes the compounded medication, the licensed physician who reviews your assessment and manages your care, shipping to your door, and unlimited messaging with your care team. Refills are the same price each month; there is no separate membership, consult, or visit fee.
The compounded Methylcobalamin (B12) from an FDA-registered 503A pharmacy, the vial with sterile syringes and alcohol prep pads, cold-chain shipping, the physician review of your assessment, ongoing physician care and dose adjustments, and unlimited messaging. If the physician does not approve you, the medication charge is refunded.
Yes. Methylcobalamin (B12) is prescription-only. At Pepti you complete a free online assessment, a licensed US physician reviews it, and if it is appropriate for you the prescription is sent to a partner pharmacy that compounds it and ships it to you. Compounded Methylcobalamin (B12) is not FDA-approved; it is prepared to a physician's prescription by a state-licensed, FDA-registered pharmacy.
No. Compounded Methylcobalamin (B12) is a cash-pay prescription and is not covered by insurance or Medicare. Most patients can use HSA or FSA funds, since it is a physician-prescribed medication. Pepti does not bill insurance, which is part of why there are no consult or visit fees.
Research-use-only peptides are sold without a prescription, without a physician, and without a pharmacy. They are labeled "not for human use" for a reason: no one is verifying the identity, purity, sterility, or dose of what is in the vial. Pepti's $229 covers a licensed physician, a state-licensed FDA-registered compounding pharmacy, and independent batch testing — potency, sterility and bacterial endotoxin — at a third-party laboratory. You are paying for the medication to be what the label says it is.
No — every medication is its own catalog price however many are in the plan. Adding a second medication to the same plan means one assessment, one physician review and one shipment — each medication keeps its own catalog price. If you want several peptides for less, a pharmacy-compounded blend puts two to four in one vial at one price.
Once per fill. One vial is your monthly supply, and a fresh one ships about every 28 days depending on the dose your physician prescribes, billed at the same $229 each time. It renews until you cancel, and you can cancel anytime from your account. There is no contract and no cancellation fee.
Most peptide clinics price Methylcobalamin (B12) as a medication fee plus an initial consult, a membership or program fee, and follow-up visit fees, and many require in-person visits. Pepti charges one monthly price of $229 that already includes the physician and shipping, with no consult, membership, or visit fees. Some clinics also dispense research-use-only peptides; Pepti dispenses only physician-prescribed, pharmacy-compounded medication.
— More questions27 more questions about Pepti, answered.
Methylcobalamin is the most active and bioavailable form of vitamin B12 — far more effective than oral B12 supplements. Supports energy, cognitive function, and nerve health. Weekly self-injection. Methylcobalamin (Active B12) is prescription-only at Pepti: a licensed physician reviews your assessment and, if appropriate, prescribes it to be compounded by a state-licensed, FDA-registered pharmacy.
Methylcobalamin (Active B12) is $229 per month at Pepti. That is all-in: medication, physician review and ongoing care, shipping, and messaging. No membership, consult, or visit fees, and the price is the same in every state.
Methylcobalamin (Active B12) is commonly prescribed for: Adults who feel tired all the time and want to rule out low B12; People on metformin, acid reducers or a plant-based diet, which all lower B12; Anyone with tingling or numbness their physician has linked to B12; Patients who want the active form rather than the cheaper cyanocobalamin. Whether it is appropriate for you is decided by the reviewing physician from your history, medications, and labs where required.
Yes. Methylcobalamin (Active B12) is prescription-only. The free online assessment takes about five minutes, a physician licensed in your state reviews it within 4 hours, and if approved the prescription goes to the pharmacy. If not approved, the medication charge is refunded.
No. Methylcobalamin (Active B12) can be prescribed from the assessment alone. Bloodwork is required only for the GLP-1s and growth-hormone secretagogues, and the intake tells you if a medication on your order needs it.
Methylcobalamin (Active B12) is a subcutaneous injection into the abdomen or thigh with a small insulin syringe. Your kit ships with sterile syringes and alcohol prep pads, and the exact dose and schedule are printed on the pharmacy label. Dosing videos are in your account.
One vial is your monthly supply at the dose your physician prescribes. A fresh vial ships about every 28 days, and the date moves if your physician changes your dose. Store it as the pharmacy label directs, refrigerated.
Once per fill, $229 each time, when the next vial ships. It renews until you cancel, which you can do anytime from your account with no cancellation fee.
The compounded Methylcobalamin (Active B12) with sterile syringes and alcohol prep pads, free tracked shipping in an unbranded box with insulated packaging, the physician review, ongoing physician care and dose adjustments, and unlimited messaging.
Reported side effects of Methylcobalamin (Active B12) are usually mild: mild redness or swelling at injection site; temporary fatigue or headache; mild nausea (uncommon). The physician screens your history, medications, and allergies before prescribing, the medication-specific consent lists the known risks, and you can message your physician about anything you notice. Seek emergency care for severe symptoms.
Response varies by person, goal, and dose, and Methylcobalamin (Active B12) is prescribed for ongoing use rather than a short trial. Your physician sets expectations at approval, tracks how you respond through your account, and adjusts the dose without an appointment.
Any dose change is made by your physician from the chart, without an appointment. Message them through your account if you think your dose should change.
Yes. Add Methylcobalamin (Active B12) to a plan with another treatment and both go through one assessment and one physician review, shipping together on one schedule. Each keeps its own catalog price. The physician reviews the combination and can adjust it.
No. Compounded Methylcobalamin (Active B12) is not FDA-approved. It is prepared to your physician's prescription by a state-licensed, FDA-registered 503A pharmacy and every batch is independently tested before release.
Yes, when prescribed by a licensed physician and dispensed by a licensed pharmacy, which is how Pepti provides it in every state it serves. Research-use-only Methylcobalamin (Active B12) sold without a prescription is labeled not for human use and is a different product.
Methylcobalamin is the active form of vitamin B12 your body uses directly, needed for energy production, red blood cells and the coating on nerves. At Pepti it is prescribed to support most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. Individual response varies, and your physician sets expectations at approval.
Methylcobalamin is the active form of vitamin B12 your body uses directly, needed for energy production, red blood cells and the coating on nerves. As a weekly injection it bypasses the gut entirely. Compounded Methylcobalamin (Active B12) is not FDA-approved; it is prescribed off-label by a licensed physician after reviewing your assessment.
Methylcobalamin (Active B12) is prescribed for most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. It is commonly requested by adults who feel tired all the time and want to rule out low B12; people on metformin, acid reducers or a plant-based diet, which all lower B12; Anyone with tingling or numbness their physician has linked to B12; patients who want the active form rather than the cheaper cyanocobalamin. Whether it is appropriate for you is the reviewing physician's decision.
Methylcobalamin (Active B12) is studied for most bioavailable form of b12, energy & cognitive support, better than oral b12, weekly injection. Those are the goals it is prescribed to support at Pepti; results vary by person, dose, and consistency, and no outcome is guaranteed. Your physician tracks how you respond through your account.
B12 injection is standard care for deficiency. In people with normal levels the energy effect is modest and is reported mostly by those who were running low. References are listed on this page.
Methylcobalamin (Active B12) is generally not prescribed with: active cancer or history of cancer (unless approved by oncologist); pregnancy or breastfeeding; severe kidney or liver disease; known allergy to the peptide or excipients. The physician screens for these in your intake, and anything that rules Methylcobalamin (Active B12) out means it is not prescribed and is refunded.
At Pepti. Complete the free assessment, a physician licensed in your state reviews it within 4 hours, and if appropriate Methylcobalamin (Active B12) is compounded by a state-licensed, FDA-registered pharmacy and shipped free to your door for $229 per month, all-in. Not prescribed means refunded.
Injectable vial: 5 mL at 2 mg/mL, containing 10 mg Methylcobalamin (B12). One vial is your monthly supply at the prescribed dose, and a fresh one ships about every 28 days.
Not currently. Methylcobalamin (Active B12) ships as a multi-dose vial with sterile syringes and prep pads. The pepti Pen is available for 10 other treatments.
$229 per month covers the compounded Methylcobalamin (Active B12), the physician review, ongoing physician care including dose adjustments and refill review, unlimited messaging, and free tracked shipping. There is no membership, consult, visit, or refill fee; the only separate charges are optional at-home lab panels and a physician-approved dose increase billed at pharmacy cost.
Yes. Methylcobalamin (Active B12) is on Pepti's live catalog, which lists only treatments a partner pharmacy can compound and ship today. If a physician prescribes it, it ships; if it ever cannot be dispensed, the charge is refunded.
Methylcobalamin (Active B12) ships to 50 states, free and tracked, in insulated unbranded packaging. Eligibility is confirmed during the assessment from your shipping address.
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